Table 2.

Odds ratio of breast cancer and 95% CI according to levels of alcohol intake by receptor status of the tumor (Italy; 1991-1994)

Never drinkers<Median* (13.8 g/d)≥Median (13.8 g/d)Per 10 g increased
Categories of alcohol consumption (g of ethanol per day)
Controls [n (%)]491 (36.4)429 (31.8)430 (31.9)
Cases [n (%)]244 (24.7)337 (34.1)408 (41.3)
OR (95% CI)11.55 (1.24-1.93)1.96 (1.57-2.47)1.11 (1.05-1.17)
ER status
ER−
    Cases [n (%)]65 (28.6)90 (39.7)72 (31.7)
    OR (95% CI)11.57 (1.09-2.26)1.36 (0.93-2.01)not given
ER+
    Cases [n (%)]179 (23.5)247 (32.4)336 (44.1)
    OR (95% CI)11.51 (1.18-1.93)2.16 (1.68-2.76)1.13 (1.07-1.20)
P heterogeneity = 0.006
ER and PR status combined
ER-PR-
    Cases [n (%)]50 (29.24)68 (39.77)53 (30.99)
    OR (95% CI)11.54 (1.02-2.32)1.25 (0.81-1.94)not given
ER+PR−
    Cases [n (%)]31 (30.69)33 (32.67)37 (36.63)
    OR (95% CI)11.02 (0.60-1.74)1.30 (0.76-2.24)1.07 (0.95-1.21)
ER−PR+
    Cases [n (%)]15 (26.79)22 (39.29)19 (33.93)
    OR (95% CI)11.63 (0.81-3.28)1.72 (0.83-3.59)1.11 (0.95-1.28)
ER+PR+
    Cases [n (%)]148 (22.39)214 (32.38)299 (45.23)
    OR (95% CI)11.60 (1.24-2.08)2.34 (1.81-3.04)1.14 (1.07-1.20)
  • Derived from multiple logistic regression, including terms for age, center, education, parity, menopausal status, age at menarche, family history of breast cancer, BMI, and energy intake. Abbreviation: OR, odds ratio.

  • * Computed on the distribution of control drinkers.

  • Reference category = nondrinkers (ex-drinkers were excluded).

  • Not given because of the lack of linearity in the categorical analysis.