Table 3.

Association between serum organochlorine pesticide concentrations and risk of TGCC

LowMediumHighPtrend*per 10 pg/g
β-hexachlorocyclohexane
    Concentration (pg/g)≤29>29-65>65
    Cases/controls (n)113/28583/20025/85
    OR (95% CI)1.00 (reference)1.26 (0.86-1.85)0.92 (0.51-1.64)0.830.97 (0.82-1.13)
γ-hexachlorocyclohexane
    Concentration (pg/g)≤9>9-20>20
    Cases/controls (n)130/31273/21738/93
    OR (95% CI)1.00 (reference)0.80 (0.53-1.20)1.36 (0.75-2.46)0.695.54 (1.65-18.56)
Dieldrin
    Concentration (pg/g)≤51>51-98>98
    Cases/controls (n)116/29586/20729/88
    OR (95% CI)1.00 (reference)1.00 (0.68-1.47)0.79 (0.44-1.41)0.530.78 (0.53-1.17)
Hexachlorobenzene
    Concentration (pg/g)≤190>190-473>473
    Cases/controls (n)139/31571/22035/94
    OR (95% CI)1.00 (reference)0.79 (0.47-1.32)0.85 (0.37-1.96)0.561.05 (0.95-1.15)
Heptachlor epoxide
    Concentration (pg/g)≤26>26-59>59
    Cases/controls (n)113/28791/20024/85
    OR (95% CI)1.00 (reference)1.25 (0.85-1.83)0.67 (0.35-1.29)0.691.04 (0.48-2.25)
Mirex
    Concentration (pg/g)≤11>11-28>28
    Cases/controls (n)125/31189/22128/93
    OR (95% CI)1.00 (reference)1.27 (0.86-1.86)0.87 (0.50-1.53)0.981.38 (0.66-2.88)
p,p′-DDT
    Concentration (pg/g)≤27>27-47>47
    Cases/controls (n)110/30194/21032/90
    OR (95% CI)1.00 (reference)1.39 (0.96-2.02)1.17 (0.68-2.00)0.301.14 (0.56-2.32)
o,p-DDT
    Concentration (pg/g)≤5>5-13>13
    Cases/controls (n)104/29083/20037/83
    OR (95% CI)1.00 (reference)1.26 (0.83-1.91)1.30 (0.67-2.53)0.280.86 (0.33-2.26)
p,p′-DDE
    Concentration (pg/g)≤1,101>1,101-2,473>2,473
    Cases/controls (n)130/31194/21821/93
    OR (95% CI)1.00 (reference)1.14 (0.78-1.67)0.61 (0.32-1.14)0.360.99 (0.97-1.01)
Oxychlordane
    Concentration (pg/g)≤43>43-97>97
    Cases/controls (n)121/29987/20929/89
    OR (95% CI)1.00 (reference)1.18 (0.80-1.73)0.93 (0.50-1.73)0.890.97 (0.58-1.63)
trans-nonachlor
    Concentration (pg/g)≤72>72-146>146
    Cases/controls (n)124/31591/22131/94
    OR (95% CI)1.00 (reference)1.16 (0.80-1.69)0.89 (0.49-1.61)0.990.87 (0.63-1.19)
Total chlordanes§
    Concentration (pg/g)≤144>144-283>283
    Cases/controls (n)120/31593/22133/94
    OR (95% CI)1.00 (reference)1.18 (0.81-1.71)0.93 (0.51-1.68)0.880.94 (0.79-1.12)
  • * Trend test done by assigning ordinal scores to pesticide categories and modeling as continuous term.

  • Except p,p′-DDE, which is per 100 pg/g.

  • Adjusted for age, race, change in BMI between reference date and blood draw, assay run number, and serum lipids.

  • § Sum of chlordane-derived compounds including oxychlordane, trans-nonachlor, and heptachlor epoxide.