Table 5.

Selected gene-vitamin B interactions and risk of colorectal adenomas

Genotypen recurrences/total
Adjusted RR (95% CI)*Pinteraction
Vitamin B level below the median (reference)Vitamin B level above the median
Baseline plasma vitamin B2 (riboflavin), nmol/L2.1-15.015.1-479.0
    MTHFR-677CC + C/T195/413179/4160.87 (0.73-1.03)
    MTHFR-677T/T18/5219/441.40 (0.85-2.30)0.07
    MTHFR-1298A/A + A/C197/431178/4160.90 (0.76-1.07)
    MTHFR-1298C/C16/3521/450.92 (0.56-1.54)0.94
Baseline plasma vitamin B6 (PLP), pmol/L21.4-300.3300.5-2,479
    CBS-1080 C/C+C/T182/403159/4020.90 (0.75-1.08)
    CBS-1080 T/T37/5632/620.72 (0.49-1.03)0.25
    CBS-699 C/C+C/T195/404179/4220.89 (0.75-1.06)
    CBS-699 T/T25/5713/440.67 (0.40-1.13)0.30
    MTHFR-677CC + C/T196/410178/4190.90 (0.76-1.07)
    MTHFR-677T/T24/5113/450.66 (0.39-1.10)0.25
Baseline plasma vitamin B12, nmol/L4.7-53.353.4-857.0
    MTR-2756A/A72/15563/1510.92 (0.71-1.20)
    MTR-2756A/G + G/G151/310127/3140.87 (0.72-1.05)0.70
    MTRR-66A/A + A/G163/335139/3420.86 (0.72-1.03)
    MTRR-66G/G59/12951/1230.96 (0.72-1.29)0.50
    MTHFR-677CC + C/T198/411177/4210.90 (0.77-1.07)
    MTHFR-677T/T24/5213/450.69 (0.41-1.17)0.33
  • * Adjusted for age, sex, center, duration of follow-up, aspirin treatment group, multivitamin use and plasma B2, B6, B12, and folate as appropriate.