Table 2.

Association of vitamin B2, B6, and B12 baseline plasma levels and risk of colorectal adenomas

Baseline plasma vitamin B level
P*
Q1Q2Q3Q4
Vitamin B2 (riboflavin), nmol/L2.1-8.99.0-15.015.1-27.527.6-479.0
All adenomas
    n recurrences/total109/247111/249104/244106/246
    Adjusted RR (95% CI)1.001.00 (0.81-1.22)0.89 (0.72-1.10)0.88 (0.71-1.10)0.18
    Adjusted RR (95% CI)1.001.01 (0.82-1.24)0.93 (0.75-1.15)0.95 (0.75-1.20)0.51
Advanced lesions
    n recurrences/total29/24722/24930/24418/246
    Adjusted RR (95% CI)1.000.76 (0.45-1.30)0.96 (0.58-1.59)0.55 (0.30-1.01)0.13
    Adjusted RR (95% CI)1.000.76 (0.44-1.31)0.95 (0.57-1.59)0.51 (0.26-0.99)0.12
    Vitamin B6 (PLP), nmol/L4.7-35.635.7-53.353.4-84.384.7-857.0
All adenomas
    n recurrences/total116/248113/245111/24890/245
    Adjusted RR (95% CI)1.000.97 (0.79-1.18)0.91 (0.74-1.12)0.75 (0.59-0.94)0.02
    Adjusted RR (95% CI)1.001.00 (0.82-1.22)0.95 (0.77-1.17)0.78 (0.61-1.00)0.08
Advanced lesions
    n recurrences/total23/24819/24536/24821/245
    Adjusted RR (95% CI)1.000.77 (0.43-1.37)1.44 (0.86-2.42)0.86 (0.46-1.60)0.73
    Adjusted RR (95% CI)1.000.77 (0.43-1.39)1.48 (0.87-2.52)0.89 (0.46-1.73)0.61
    Vitamin B12, pmol/L21.4-235.9236.4-300.3300.5-388.8389.2-2,479
All adenomas
    n recurrences/total115/249119/24698/24899/247
    Adjusted RR (95% CI)1.001.02 (0.84-1.25)0.85 (0.69-1.05)0.88 (0.71-1.11)0.12
    Adjusted RR (95% CI)1.001.02 (0.84-1.25)0.86 (0.69-1.06)0.91 (0.73-1.15)0.22
Advanced lesions
    n recurrences/total27/24928/24619/24825/247
    Adjusted RR (95% CI)1.001.01 (0.61-1.70)0.69 (0.39-1.24)0.95 (0.53-1.68)0.57
    Adjusted RR (95% CI)1.001.02 (0.61-1.71)0.69 (0.38-1.24)0.94 (0.52-1.69)0.55
  • * Ptrend.

  • Adjusted for age, sex, center, duration of follow-up, aspirin treatment group, and multivitamin use.

  • Adjusted for age, sex, center, duration of follow-up, aspirin treatment group, multivitamin use, and plasma B2, B6, B12, and folate as appropriate.