Table 3.

HRs and 95% CIs of colon and rectal cancer according to quartile of energy-adjusted intake of isoflavones, miso soup, and soy food in the JPHC study

Men
Women
Colon
Rectum
Colon
Rectum
No. casesHR (95% CI)*No. casesHR (95% CI)*No. casesHR (95% CI)*No. casesHR (95% CI)*
Isoflavones
    Lowest831.00 (Reference)331.00 (Reference)541.00 (Reference)241.00 (Reference)
    2nd950.97 (0.72-1.31)461.28 (0.81-2.02)560.89 (0.61-1.31)210.85 (0.46-1.54)
    3rd890.85 (0.62-1.17)511.34 (0.84-2.13)670.96 (0.66-1.40)301.21 (0.68-2.15)
    Highest830.76 (0.55-1.07)481.17 (0.72-1.91)821.11 (0.77-1.61)240.97 (0.52-1.79)
P for trend0.080.610.430.79
Miso soup
    Lowest771.00 (Reference)361.00 (Reference)541.00 (Reference)171.00 (Reference)
    2nd900.98 (0.72-1.33)491.19 (0.77-1.85)590.95 (0.65-1.38)241.31 (0.70-2.46)
    3rd920.90 (0.66-1.24)531.16 (0.75-1.80)771.05 (0.73-1.50)271.44 (0.77-2.69)
    Highest910.85 (0.61-1.17)400.78 (0.49-1.26)690.88 (0.60-1.27)311.62 (0.87-3.02)
P for trend0.270.270.600.13
Soy food
    Lowest851.00 (Reference)321.00 (Reference)551.00 (Reference)271.00 (Reference)
    2nd1010.99 (0.74-1.33)451.26 (0.79-2.00)600.91 (0.63-1.33)220.78 (0.44-1.39)
    3rd840.78 (0.57-1.07)541.40 (0.88-2.22)660.93 (0.64-1.34)250.87 (0.49-1.54)
    Highest800.77 (0.55-1.06)471.20 (0.74-1.95)781.11 (0.77-1.60)250.90 (0.50-1.62)
P for trend0.050.470.520.82
  • * Adjusted for age (continuous); public health center area (nine centers); history of diabetes mellitus (yes or no); body mass index (<20, 21-22, 23-24, ≥25 kg/m2); leisure time physical activity (rarely, 1-3 d per month, 1-2 d per week, frequently); cigarette smoking (never, past, current 1-19 cigarettes per day, current ≥20 cigarettes per day); alcohol drinking (nondrinker, 1-3 d per month, <100 g ethanol per week, ≥100 g ethanol per week); and intake of vitamin D, dairy products, meat, vegetable, fruit, and fish (energy-adjusted quartiles). Also adjusted for menopausal status (pre or post) and current use of female hormones (user or nonuser) in women only.