Table 2.

HRs and 95% CIs of colorectal cancer according to quartile of energy-adjusted intake of isoflavones, miso soup, and soy food in the JPHC study

Men
Women
No. of colorectal casesPerson-yearsAge-adjusted incidence rate (per 1,000)HR (95% CI)*No. of colorectal casesPerson-yearsAge-adjusted incidence rate (per 1,000)HR (95% CI)*
Isoflavones
    Lowest11670,26912.501.00 (Reference)7881,0227.161.00 (Reference)
    2nd14173,92814.451.06 (0.82-1.36)7785,9477.090.88 (0.64-1.21)
    3rd14075,20714.250.98 (0.75-1.28)9787,3558.551.02 (0.74-1.40)
    Highest13173,03313.120.89 (0.67-1.17)10685,9679.341.07 (0.78-1.47)
P for trend0.250.44
Miso soup
    Lowest11368,20112.171.00 (Reference)7178,9466.601.00 (Reference)
    2nd13971,60414.271.05 (0.81-1.35)8382,2887.651.04 (0.75-1.43)
    3rd14576,17214.660.98 (0.76-1.27)10488,3419.221.14 (0.84-1.56)
    Highest13176,46012.760.88 (0.64-1.10)10090,7258.671.03 (0.75-1.43)
P for trend0.130.74
Soy food
    Lowest11769,82512.771.00 (Reference)8280,5107.641.00 (Reference)
    2nd14674,36615.031.06 (0.83-1.36)8285,8027.420.87 (0.64-1.18)
    3rd13875,56913.720.94 (0.73-1.22)9188,2018.100.90 (0.66-1.23)
    Highest12772,67812.720.89 (0.68-1.17)10385,7879.041.04 (0.76-1.42)
P for trend0.220.69
  • * Adjusted for age (continuous); public health center area (nine centers); history of diabetes mellitus (yes or no); body mass index (<20, 21-22, 23-24, ≥25 kg/m2); leisure time physical activity (rarely, 1-3 d per month, 1-2 d per week, frequently); cigarette smoking (never, past, current 1-19 cigarettes per day, current ≥20 cigarettes per day); alcohol drinking (nondrinker, 1-3 d per month, <100 g ethanol per week, ≥100 g ethanol per week); and intake of vitamin D, dairy products, meat, vegetable, fruit, and fish (energy-adjusted quartiles). Also adjusted for menopausal status (pre or post) and current use of female hormones (user or nonuser) in women only.