Table 2.

ORs and 95% CIs for biliary tract cancers and stones in relation to polymorphisms of DNA repair genes

Controls
Biliary tract cancers
Biliary stones*
Gallbladder
Bile duct
Ampulla of Vater
nnOR (95% CI)§nOR (95% CI)§nOR (95% CI)§nOR (95% CI)§
Total78623612747891
CCNH EX7+49T>C (rs2266690)
    TT6371901.00 (—)1081.00 (—)391.007041.00 (—)
    TC140431.00 (0.68-1.47)180.74 (0.43-1.27)80.97 (0.44-2.14)1681.09 (0.83-1.43)
    CC6200102.49 (0.67-9.23)
    TC+CC146450.99 (0.68-1.45)180.72 (0.42-1.23)80.94 (0.43-2.06)1781.13 (0.86-1.47)
        P0.950.200.790.27
RAD23B IVS5-15A>G (rs1805335)
    AA4571221.00 (—)751.00 (—)281.00 (—)5241.00 (—)
    AG2881011.32 (0.97-1.79)420.90 (0.60-1.36)181.02 (0.55-1.89)3151.04 (0.83-1.29)
    GG35131.40 (0.71-2.76)91.43 (0.65-3.13)1461.10 (0.67-1.79)
    AG+GG3231141.33 (0.98-1.79)510.96 (0.65-1.42)190.97 (0.53-1.77)3611.04 (0.84-1.29)
        P0.070.830.730.66
RAD23B EX7+65C>T (rs1805329)
    CC5181421.00 (—)851.00 (—)321.00 (—)5841.00 (—)
    CT237881.35 (0.99-1.84)360.94 (0.61-1.43)140.94 (0.49-1.81)2741.13 (0.89-1.42)
    TT2470.97 (0.41-2.31)51.18 (0.43-3.23)1250.80 (0.44-1.46)
    CT+TT261951.31 (0.97-1.77)410.96 (0.64-1.44)150.93 (0.49-1.75)2991.09 (0.87-1.37)
        P0.160.960.770.69
XRCC3 EX8-53C>T (rs861539)
    CC6752051.00 (—)1151.00 (—)411.00 (—)7861.00 (—)
    CT103280.85 (0.54-1.33)100.58 (0.29-1.15)61.00 (0.41-2.43)910.72 (0.52-0.99)
    TT20004
    CT+TT105280.83 (0.53-1.30)100.57 (0.29-1.13)60.99 (0.41-2.39)950.74 (0.54-1.02)
        P0.350.100.950.12
MGMT EX5-25>T (rs12917)
    CC6312051.00 (—)1081.00391.00 (—)7091.00 (—)
    CT144300.67 (0.43-1.02)160.64 (0.36-1.12)70.78 (0.34-1.79)1631.11 (0.84-1.47)
    TT7001111.17 (0.42-3.24)
    CT+TT151300.63 (0.41-0.97)160.61 (0.35-1.06)80.85 (0.39-1.87)1741.11 (0.85-1.46)
        P0.020.060.860.43
  • NOTE: The total number of subjects in some columns may vary across SNPs because of missing values.

  • * Biliary stone cases compared with controls without stones (n = 592).

  • Gallbladder cancer cases compared with controls with a gallbladder (n = 737).

  • Bile duct and ampulla of Vater cancer cases compared with all controls (n = 786).

  • § Adjusted for age group and sex.

  • Test of trend or Pearson χ2 test if variant genotype is <5.