Table 5.

Association of SNPs in APC and AXIN2 with breast cancer by ER, PR, and HER2 status of tumors

Gene namersIDER positive (Nca = 483, Nco = 843)
PR positive (Nca = 437, Nco = 843)
HER2 positive (Nca = 127, Nco = 843)
OR (95% CI) per allelePtrend*OR (95% CI) per allelePtrend*OR (95% CI) per allelePtrend*
APCrs119548560.85 (0.72-1.01)0.060.89 (0.74-1.06)0.180.89 (0.67-1.18)0.43
APCrs112411830.87 (0.74-1.03)0.110.91 (0.77-1.09)0.310.91 (0.69-1.20)0.51
APCrs24395910.87 (0.73-1.03)0.100.91 (0.76-1.09)0.301.03 (0.78-1.37)0.83
APCrs24315120.86 (0.73-1.02)0.080.90 (0.76-1.07)0.230.92 (0.69-1.21)0.55
APCrs24312380.84 (0.70-1.00)0.060.88 (0.74-1.06)0.190.98 (0.73-1.32)0.89
APCrs4548861.20 (1.00-1.44)0.041.16 (0.96-1.39)0.131.16 (0.86-1.56)0.34
APCrs5012500.86 (0.72-1.02)0.080.90 (0.75-1.07)0.241.03 (0.77-1.36)0.86
APCrs22299920.88 (0.75-1.04)0.150.93 (0.78-1.10)0.401.00 (0.76-1.32)0.99
APCrs131675220.81 (0.61-1.08)0.150.90 (0.67-1.20)0.470.92 (0.57-1.46)0.71
APCrs411160.87 (0.74-1.03)0.110.91 (0.77-1.09)0.310.89 (0.68-1.18)0.42
APCrs4484750.87 (0.73-1.03)0.100.91 (0.76-1.08)0.280.88 (0.67-1.17)0.39
AXIN2rs72103561.34 (1.03-1.73)0.031.38 (1.06-1.80)0.021.10 (0.69-1.73)0.69
AXIN2rs47911711.14 (0.95-1.36)0.171.15 (0.95-1.39)0.141.25 (0.92-1.69)0.15
AXIN2rs110795711.25 (1.01-1.56)0.041.30 (1.04-1.63)0.021.44 (1.00-2.06)0.05
AXIN2rs39230871.10 (0.90-1.34)0.371.12 (0.92-1.38)0.261.30 (0.95-1.79)0.10
AXIN2rs39230861.07 (0.91-1.27)0.401.10 (0.93-1.31)0.271.13 (0.85-1.50)0.39
  • NOTE: Logistic regression analysis was adjusted for age, geographic region, menopausal status, age at menarche, oral contraceptive use, age at first birth, hormone replacement therapy, and cigarette smoking in pack-years.

    Abbreviations: rsID: SNP identification number; Nca, number of cases; Nco, number of controls.

  • * The false-positive probability q values were not calculated.