Table 4.

Association of APC and AXIN2 SNPs with breast cancer risk in premenopausal and postmenopausal women

Gene namersIDPremenopausal women (Nca = 273, Nco = 220)
Postmenopausal women (Nca = 480, Nco = 579)
OR (95% CI) per allelePtrendq valueOR (95% CI) per allelePtrendq value
APCrs119548560.79 (0.60-1.03)0.090.240.84 (0.70-1.01)0.060.20
APCrs112411830.75 (0.57-0.98)0.040.170.86 (0.72-1.03)0.090.24
APCrs24395910.90 (0.68-1.19)0.440.450.80 (0.67-0.97)0.020.17
APCrs24315120.74 (0.56-0.97)0.030.170.86 (0.72-1.03)0.100.24
APCrs24312380.87 (0.65-1.16)0.340.440.81 (0.67-0.98)0.030.17
APCrs4548861.26 (0.95-1.69)0.110.251.19 (0.98-1.45)0.070.22
APCrs5012500.87 (0.66-1.15)0.330.440.81 (0.67-0.97)0.030.17
APCrs22299920.85 (0.65-1.12)0.260.400.82 (0.69-0.99)0.040.17
APCrs131675220.57 (0.36-0.91)0.020.170.86 (0.63-1.17)0.330.44
APCrs411160.76 (0.58-1.00)0.050.190.86 (0.72-1.03)0.110.25
APCrs4484750.75 (0.57-0.98)0.040.170.86 (0.72-1.03)0.100.24
APC*rs172904560.52 (0.30-0.88)0.020.170.85 (0.59-1.24)0.400.44
AXIN2*rs75911.46 (1.08-1.96)0.010.171.03 (0.85-1.23)0.790.56
AXIN2rs72103561.53 (0.98-2.40)0.060.201.19 (0.90-1.57)0.220.35
AXIN2rs47911711.84 (1.34-2.53)0.00020.021.01 (0.84-1.23)0.880.59
AXIN2rs110795711.78 (1.21-2.63)0.0040.161.10 (0.87-1.39)0.430.44
AXIN2rs39230871.62 (1.14-2.28)0.0070.171.03 (0.83-1.27)0.790.56
AXIN2rs39230861.44 (1.08-1.93)0.010.171.08 (0.90-1.29)0.420.44
  • NOTE: Logistic regression analysis was adjusted for age, geographic region, age at menarche, oral contraceptive use, age at first birth, hormone replacement therapy, and pack-years of cigarette smoking.

    Abbreviations: rsID: SNP identification number; Nca, number of cases; Nco, number of controls.

  • * Nonsignificant association in complete case-control study population.