Table 3.

Association of APC and AXIN2 haplotypes with breast cancer risk

Haplotype blocksSNP combinations*Hap-frequencyHap-scoreHaplotype P§
APC block 1112222210.3192.160.03
222212110.084−0.530.60
112222110.029−0.070.95
111212110.042−0.060.95
111111110.193−0.020.98
111111120.3102.730.006
APC block 2212222210.063−1.560.12
212222110.028−1.100.27
112211120.097−0.750.45
122222110.175−0.660.51
122221110.041−0.650.51
112211110.044−0.080.94
112222110.0430.680.49
111111110.5002.330.02
AXIN2 block 1121110.464−0.930.35
211110.141−0.680.49
112110.069−0.470.64
112210.2100.280.78
112120.1082.200.03
  • NOTE: Haplotypes with frequency > 2% are shown in the table and those with P < 0.05 are underlined. APC block 1: rs2464810, rs1882619, rs11954856, rs11241183, rs2439591, rs2431512, rs2431238, and rs454886; APC block 2: rs13167522, rs459552, rs41116, rs448475, rs397768, rs431287, rs17290456, and rs12152991; AXIN2 block 1: rs12452196, rs11868547, rs7591, rs4074947, and rs7210356.

  • * 1, major allele; 2, minor allele.

  • Frequency of each haplotype in the cases and controls.

  • Statistical measurement of association of each specific haplotype with breast cancer risk.

  • § Haplotype of interest compared with all other haplotypes (frequency >2%) combined.