Table 2.

Multivariate analysis of polymorphic variants of APC and AXIN2 genes

Gene namersIDHomozygotes, major allele
Heterozygotes
Homozygotes, minor allele
OR (95% CI) per allelePtrend*
CasesControlsCasesControlsCasesControls
APCrs119548562612293864301501810.84 (0.72-0.97)0.02
APCrs112411832231903914321842210.84 (0.73-0.97)0.02
APCrs2439591366333339394931150.85 (0.74-0.99)0.04
APCrs24315122251923914311822200.84 (0.73-0.97)0.02
APCrs243123840036031738781950.85 (0.73-0.99)0.04
APCrs45488635842234635594661.23 (1.05-1.43)0.01
APCrs501250346318352397991270.85 (0.73-0.98)0.03
APCrs22299923172843624091181490.85 (0.74-0.99)0.04
APCrs13167522675677117157690.77 (0.60-0.98)0.04
APCrs411162241923904311842200.85 (0.73-0.98)0.02
APCrs4484752241913904301842210.84 (0.73-0.97)0.02
AXIN2rs72103566266771541591861.28 (1.02-1.60)0.04
AXIN2rs479117138343333234983611.19 (1.02-1.39)0.03
AXIN2rs1107957153360623322132161.28 (1.05-1.54)0.01
AXIN2rs392308745852529227847391.19 (1.00-1.41)0.04
AXIN2rs39230862382843954191641391.18 (1.02-1.36)0.03
  • NOTE: Logistic regression analysis was adjusted for age, geographic region, menopausal status, age at menarche, oral contraceptive use, age at first birth, hormone replacement therapy, and pack-years of cigarette smoking.

    Abbreviation: rsID, SNP identification number.

  • * For these ordinal P values, the false-positive probability q = 0.15 except for rs3923087 (q = 0.16).