Table 1.

Adverse events by category and dosage

Adverse event100 mg n (%)250 mg n (%)500 mg n (%)1,000 mg n (%)1,500 mg n (%)2,000 mg n (%)
Total0 (0)2 (66.6)1 (33.3)3 (50.0)2 (66.6)6 (66.6)
Fatigue*0 (0)1 (33.3)0 (0)1 (16.6)1 (33.3)0 (0)
Gastrointestinal symptoms0 (0)0 (0)1 (33.3)1 (16.6)2 (66.6)4 (44.4)
Headache0 (0)1 (33.3)0 (0)1 (16.6)1 (33.3)1 (11.1)
Other0 (0)0 (0)0 (0)0 (0)1 (33.3)1 (11.1)
  • NOTE: National Cancer Institute Common Toxicity Criteria v.2.0.

  • * Fatigue includes difficulty concentrating.

  • Gastrointestinal symptoms include eructation, heartburn, and indigestion.

  • Other includes decreased heart rate and burning with urination.