Table 2.

Age-adjusted ORs for BMI and weight by tumor subtype and current HT use

Controls
Luminal cases
HER2-overexpressing cases
Triple-negative cases
n (%)n (%)OR* (95% CI)n (%)OR* (95% CI)n (%)OR* (95% CI)
BMI, kg/m2
Overall
    NHLBI category
        <25.0560 (39)365 (36)1.0 (Reference)15 (38)1.0 (Reference)24 (31)1.0 (Reference)
        25.0-29.9484 (33)346 (34)1.1 (0.9-1.3)11 (28)0.8 (0.4-1.8)26 (34)1.2 (0.7-2.1)
        ≥30.0403 (28)297 (29)1.1 (0.9-1.3)13 (33)1.1 (0.5-2.4)27 (35)1.4 (0.8-2.5)
        Trend testP = 0.33P = 0.78P = 0.26
    Quartiles
        <23.4365 (25)211 (21)1.0 (Reference)10 (26)1.0 (Reference)14 (18)1.0 (Reference)
        23.4-26.5358 (25)274 (27)1.3 (1.0-1.7)†7 (18)0.7 (0.3-1.9)21 (27)1.5 (0.7-3.0)
        26.6-30.5363 (25)252 (25)1.2 (0.9-1.5)10 (26)1.0 (0.4-2.4)15 (19)1.0 (0.5-2.2)
        >30.5361 (25)271 (27)1.3 (1.0-1.6)12 (31)1.1 (0.5-2.7)27 (35)1.7 (0.9-3.3)
        Trend testP = 0.13P = 0.62P = 0.21
    Continuous (per kg/m2)1.01 (1.00-1.03)1.02 (0.97-1.08)1.02 (0.97-1.08)
No current HT use
    NHLBI category
        <25.0279 (36)156 (30)1.0 (Reference)8 (35)1.0 (Reference)11 (24)1.0 (Reference)
        25.0-29.9260 (33)182 (35)1.2 (0.9-1.6)6 (26)0.8 (0.3-2.3)15 (33)1.4 (0.6-3.1)
        ≥30.0245 (31)177 (34)1.3 (1.0-1.7)9 (39)1.2 (0.4-3.1)19 (42)1.7 (0.8-3.6)
        Trend testP = 0.10P = 0.73P = 0.18
    Quartiles
        <23.4191 (24)83 (16)1.0 (Reference)6 (26)1.0 (Reference)5 (11)1.0 (Reference)
        23.4-26.5170 (22)134 (26)1.8 (1.3-2.5)†3 (13)0.5 (0.1-2.2)13 (29)2.8 (1.0-7.9)
        26.6-30.5202 (26)131 (25)1.5 (1.1-2.1)†6 (26)0.9 (0.3-2.9)8 (18)1.5 (0.5-4.6)
        >30.5221 (28)167 (32)1.7 (1.2-2.4)†8 (35)1.0 (0.3-3.1)19 (42)2.7 (1.0-7.5)
        Trend testP = 0.02P = 0.74P = 0.14
    Continuous (per kg/m2)1.03 (1.01-1.05)†1.04 (0.98-1.11)1.04 (0.99-1.08)
Current HT use
    NHLBI category
        <25.0281 (42)209 (42)1.0 (Reference)7 (44)1.0 (Reference)13 (41)1.0 (Reference)
        25.0-29.9224 (34)164 (33)1.0 (0.7-1.3)5 (31)0.9 (0.3-2.8)11 (34)1.0 (0.4-2.2)
        ≥30.0158 (24)120 (24)1.0 (0.7-1.4)4 (25)0.9 (0.3-3.2)8 (25)1.0 (0.4-2.4)
        Trend testP = 0.97P = 0.88P = 0.92
    Quartiles
        <23.4174 (26)128 (26)1.0 (Reference)4 (25)1.0 (Reference)9 (28)1.0 (Reference)
        23.4-26.5188 (28)140 (28)1.0 (0.7-1.4)4 (25)0.9 (0.2-3.7)8 (25)0.8 (0.3-2.2)
        26.6-30.5161 (24)121 (25)1.0 (0.7-1.4)4 (25)1.0 (0.2-4.2)7 (22)0.8 (0.3-2.2)
        >30.5140 (21)104 (21)1.0 (0.7-1.4)4 (25)1.1 (0.3-4.7)8 (25)1.0 (0.4-2.6)
        Trend testP = 0.96P = 0.82P = 0.94
    Continuous (per kg/m2)1.00 (0.98-1.02)0.98 (0.89-1.07)1.00 (0.93-1.06)
Weight, lb
Overall
    Quartiles
        <121366 (25)200 (20)1.0 (Reference)8 (21)1.0 (Reference)9 (13)1.0 (Reference)
        121-139380 (26)285 (28)1.3 (1.1-1.7)†11 (28)1.3 (0.5-3.2)26 (33)2.5 (1.2-5.4)†
        140-162346 (24)250 (25)1.3 (1.0-1.6)7 (18)0.9 (0.3-2.4)19 (24)1.9 (0.9-4.4)
        >162355 (25)273 (27)1.3 (1.1-1.7)†13 (33)1.5 (0.6-3.7)23 (31)2.1 (1.0-4.7)
        Trend testP = 0.04P = 0.50P = 0.20
        Continuous (per lb)1.01 (1.00-1.01)†1.01 (0.99-1.03)1.01 (1.00-1.02)
No current HT use
    Quartiles
        <121188 (24)82 (16)1.0 (Reference)5 (22)1.0 (Reference)2 (4)1.0 (Reference)
        121-139205 (26)134 (26)1.5 (1.1-2.1)†7 (30)1.2 (0.4-4.0)17 (38)7.2 (1.6-31.6)†
        140-162176 (22)133 (26)1.7 (1.2-2.4)†2 (9)0.4 (0.1-2.1)11 (24)5.1 (1.1-23.7)†
        >162215 (27)166 (32)1.7 (1.2-2.4)†9 (39)1.4 (0.4-4.3)15 (33)5.1 (1.1-23.0)†
        Trend testP < 0.01P = 0.79P = 0.18
        Continuous (per lb)1.01 (1.01-1.02)†1.01 (0.98-1.03)1.01 (0.99-1.03)
Current HT use
    Quartiles
        <121178 (27)118 (24)1.0 (Reference)3 (19)1.0 (Reference)7 (22)1.0 (Reference)
        121-139175 (26)151 (31)1.2 (0.9-1.7)4 (25)1.2 (0.3-5.6)9 (28)1.1 (0.4-3.2)
        140-162170 (26)117 (24)1.0 (0.7-1.4)5 (31)1.5 (0.4-6.6)8 (25)1.0 (0.3-2.8)
        >162140 (21)107 (22)1.1 (0.8-1.5)4 (25)1.5 (0.4-6.7)8 (25)1.2 (0.4-3.3)
        Trend testP = 0.97P = 0.54P = 0.87
        Continuous (per lb)1.00 (0.99-1.01)1.00 (0.97-1.04)1.01 (0.98-1.03)

  • Abbreviation: NHLBI, National Heart Blood and Lung Institute.

  • ↵* OR adjusted for age and reference year.

  • ↵† P < 0.05.