Table 3.

Association between individual SNPs in CSA and CSB and number of BPDE-induced chromatid breaks per cell

SNPChromosomePositionGeneAllele*Minor allele frequencyEffect per SNP allele
P
Estimate95% CI
rs12522154chr560217257CSAT:C0.330.880.79-0.970.012
rs4647132chr560218477CSAC:T0.411.040.94-1.160.424
rs4647128chr560219301CSAT:C0.040.880.67-1.170.388
rs4235483chr560223979CSAC:T0.360.870.79-0.960.005
rs929780chr560224783CSAG:C0.100.970.82-1.150.722
rs4647100chr560236422CSAA:G0.230.850.75-0.960.007
rs4647078chr560252795CSAG:A0.221.141.02-1.280.023
rs3797559chr560259498CSAA:G0.421.040.94-1.150.414
rs158937chr560271963CSAG:A0.100.970.82-1.150.727
rs4647028chr560277583CSAG:T0.230.850.75-0.950.006
rs7722373chr560283572CSAG:A0.461.030.93-1.140.594
rs158926chr560286964CSAG:T0.221.141.02-1.280.023
rs158923chr560289598CSAT:C0.360.870.78-0.960.004
rs4253234chr1050336488CSBG:C0.391.070.97-1.180.180
rs4253226chr1050337451CSBT:C0.181.110.97-1.260.117
rs3810945chr1050339175CSBC:T0.091.070.90-1.260.456
rs2228526chr1050348723CSBT:C0.190.880.79-0.990.039
rs4240506chr1050361015CSBC:T0.500.980.89-1.090.762
rs4253126chr1050372196CSBG:T0.101.130.96-1.330.144
rs7903930chr1050374003CSBG:C0.131.070.92-1.240.385
rs4253101chr1050383065CSBT:G0.190.870.77-0.980.019
rs4253079chr1050392831CSBT:G0.110.860.73-1.000.055
rs4253077chr1050392975CSBC:A0.111.070.92-1.260.374
rs2281792chr1050397362CSBT:C0.411.080.98-1.190.123
rs4253049chr1050401891CSBG:A0.180.880.78-0.990.038
rs7903788chr1050403985CSBG:C0.131.080.93-1.260.310
rs4253026chr1050409122CSBG:A0.091.080.91-1.280.352
rs4253023chr1050409269CSBC:G0.120.860.74-1.010.059
rs1012554chr1050409563CSBT:C0.291.090.98-1.220.119
rs4253009chr1050411435CSBC:T0.470.990.89-1.090.798
rs1917800chr1050420923CSBC:G0.111.110.95-1.280.186
rs6537539chr1050426040CSBT:G0.230.950.85-1.070.414
rs2377902chr1050427510CSBA:G0.410.890.81-0.980.022
rs10776579chr1050431373CSBC:T0.191.100.96-1.270.150
rs1917822chr1050432753CSBA:G0.430.960.86-1.070.420
rs2222638chr1050433801CSBG:A0.201.090.96-1.230.170
rs10776581chr1050435466CSBT:C0.441.010.92-1.110.841
  • * The latter allele is the minor one.

  • Estimate is the ratio of mean number of breaks per cell between heterozygotes and common homozygotes or between rare homozygotes and heterozygotes. These two ratios were assumed to be the same because the additive model was used in the analysis.

  • Adjustment for gender, seeding count, and current smoking status was included in the multiple linear regression model.