Table 3.

Lynch syndrome-associated cancers among mutation carriers

Type of tumorMLH1 (n = 112)
MSH2 (n = 173)
P
Frequency (%)Frequency (%)
Colorectal88 (79)119 (69)0.08
Endometrial22 (20)46 (27)0.33
Other*10 (9)41 (24)0.001
    Urinary tract tumors411
        Renal/kidney16
        Ureter23
        Bladder14
    Brain02
    Biliary10
    Stomach03
    Small intestine/duodenum03
    Ovary311
    Sebaceous213
    Pancreas00
  • * Four MSH2 mutation carriers reported more than one Lynch syndrome–related cancer other than colorectal or endometrial cancer.

  • P = 0.05.