Table 2.

Age of diagnosis among mutation carriers

Gene mutation
P
MLH1MSH2
Mean youngest age of diagnosis (±SE), y
    Carrier
        CRC42.2 (±0.9)44.8 (±0.7)0.03
        Endometrial cancer45.8 (±0.5)45.5 (±0.4)0.69
        Other HNPCC* cancer49.1 (±3.2)49.6 (±2.0)0.92
    Relatives
        FDR
            CRC41.1 (±1.3)44.8 (±1.1)0.03
            Endometrial cancer48.0 (±1.2)46.2 (±1.5)0.38
            Other HNPCC49.9 (±3.1)50.0 (±2.0)1.00
        SDR
            CRC43.6 (±1.7)52.2 (±1.8)<0.01
            Endometrial cancer48.3 (±2.2)48.4 (±3.0)1.00
            Other HNPCC48.8 (±3.7)50.9 (±3.9)0.72
        FDR + SDR
            CRC40.5 (±1.2)44.6 (±1.1)0.01
            Endometrial cancer46.8 (±1.1)45.8 (±1.3)0.55
            Other HNPCC49.2 (±2.4)50.2 (±1.9)0.77
  • NOTE: Carriers of MLH1 and MSH2 gene mutations.

  • * HNPCC includes cancers in the colorectum, kidney, ureter, bladder, brain, biliary tract, stomach, small intestine, ovary, pancreas, and sebaceous neoplasms.

  • A weighted sum of cancer diagnoses among FDR + SDR is used to incorporate the effect of genetic distance. Cancer diagnoses in SDR were weighted half that in FDR (12).