Table 2.

Distribution of AhR genotypes and urinary 1-OHP levels

GenotypesNonexposure workers
Exposure workers
n1-OHP levels (μmol/mol Cr, G ± SG)P*n1-OHP levels (μmol/mol Cr, G ± SG)P*
rs206685369147
    GG260.84 ± 0.32Reference6310.91 ± 1.20Reference
    AG300.71 ± 0.310.5017413.32 ± 1.140.146
    AA130.62 ± 0.370.288108.97 ± 1.520.774
    Trend0.2120.811
rs1025082269147
    TT240.77 ± 0.36Reference4714.48 ± 1.29Reference
    CT350.72 ± 0.310.195719.83 ± 1.050.032
    CC100.75 ± 0.300.9762913.79 ± 1.250.549
    Trend0.7680.114
rs147608069147
    AA540.74 ± 0.31Reference10812.16 ± 1.14Reference
    AC130.81 ± 0.380.6023411.45 ± 1.480.516
    CC20.27 ± 0.150.01959.86 ± 0.660.56
    Trend0.2710.91
rs1024715869147
    AA440.72 ± 0.29Reference9312.37 ± 1.15Reference
    AT220.84 ± 0.370.7115111.45 ± 1.300.328
    TT30.35 ± 0.270.22637.18 ± 1.010.415
    Trend0.7320.12
rs781198969147
    GG310.63 ± 0.30Reference5811.36 ± 1.41Reference
    AG330.87 ± 0.350.9457711.98 ± 1.030.383
    AA50.63 ± 0.190.3521214.48 ± 1.330.516
    Trend0.7750.784
rs228288569147
    TT430.73 ± 0.36Reference8213.51 ± 1.23Reference
    CT210.80 ± 0.260.2485810.37 ± 1.010.044
    CC50.59 ± 0.310.4979.41 ± 2.220.338
    Trend0.9230.041
rs696016569147
    AA430.72 ± 0.33Reference8710.93 ± 1.24Reference
    AG230.77 ± 0.340.6494613.12 ± 1.200.289
    GG30.84 ± 0.210.3631414.73 ± 0.880.379
    Trend0.6280.609
  • * Multiple analysis of covariance tests for differences in ln-transformed 1-OHP between genotypes with adjustment for sex, age, cigarettes per day, and PAH external exposure categories.

  • Reference group for comparisons of ln-transformed 1-OHP concentration between genotypes.

  • Multivariate linear regression for the trend of urinary 1-OHP levels with genotypes with adjustment for sex, age, cigarettes per day, and PAH external exposure categories.