Table 2.

Changes in serum estrone (E₁), estrone sulfate (E₁S), and the ratio of E₁S/E₁ by treatment arm

A. Baseline, 12 mo, and change in serum E₁S (ng/mL) by treatment arm
	n	Baseline					12 mo					Change (12 mo − baseline)
	n			Mean	95% CI	P	Mean	95% CI	P	Mean	95% CI	P
CEE only (reference)	105	0.65	0.59-0.71	—	2.58	2.29-2.86	—	1.93	1.65-2.20	—
CEE + MPA cyclic	103	0.59	0.53-0.64	0.14	2.86	2.53-3.19	0.20	2.27	1.95-2.60	0.11
CEE + MPA continuous	113	0.60	0.55-0.65	0.21	2.58	2.30-2.86	0.99	1.98	1.71-2.25	0.79
CEE + microP	107	0.69	0.63-0.74	0.37	3.18	2.80-3.55	0.01	2.49	2.13-2.85	0.01
Estrogen + progestogen groups combined	323	0.62	0.59-0.66	0.45	2.87	2.68-3.06	0.09	2.24	2.06-2.43	0.06

B. Baseline, 12 mo, and change in E₁ (pg/mL) by treatment arm
	n	Baseline					12 mo					Change (12 mo − baseline)
	n			Mean	95% CI	P	Mean	95% CI	P	Mean	95% CI	P
CEE only (reference)	105	15.8	14.3-17.3	—	118	105-130	—	102	89.0-115	—
CEE + MPA cyclic	103	15.3	14.1-16.6	0.65	111	98.3-124	0.46	95.6	83.0-108	0.49
CEE + MPA continuous	113	16.1	14.6-17.6	0.75	110	98.4-121	0.37	93.8	82.5-105	0.35
CEE + microP	107	17.4	15.3-19.6	0.21	103	92.6-114	0.08	86.0	75.5-96.5	0.06
Estrogen + progestogen groups combined	323	16.3	15.3-17.3	0.58	108	101-115	0.17	91.8	85.2-98.4	0.15

C. Baseline, 12 mo, and change in E₁S/E₁ [nmol/L]/[nmol/L] by treatment arm
	n	Baseline					12 mo					Change (12 mo − baseline)
	n			Mean	95% CI	P	Mean	95% CI	P	Mean	95% CI	P
CEE only (reference)	105	35.9	32.0-39.9	—	18.5	17.0-20.0	—	−17.4	−21.7 to −13.1	—
CEE + MPA cyclic	103	31.7	26.9-36.6	0.19	21.9	20.0-23.8	0.01	−9.9	−15.0 to −4.8	0.03
CEE + MPA continuous	113	32.9	29.9-35.9	0.22	20.2	18.2-22.2	0.19	−12.7	−16.0 to −9.5	0.09
CEE + microP	107	36.3	32.6-40.0	0.89	25.4	23.1-27.8	0.0000	−11.2	−14.9 to −7.5	0.03
Estrogen + progestogen groups combined	323	33.6	31.4-35.9	0.32	22.5	21.2-23.7	0.0001	−11.3	−13.6 to −9.0	0.01

NOTE: P value is for the two-sample t test for the null hypothesis that the mean value for the listed treatment group is equal to the mean value of the CEE-alone treatment group.
Abbreviation: 95% CI, 95% confidence interval.