Table 2.

Changes in serum estrone (E1), estrone sulfate (E1S), and the ratio of E1S/E1 by treatment arm

A. Baseline, 12 mo, and change in serum E1S (ng/mL) by treatment arm
nBaseline
12 mo
Change (12 mo − baseline)
Mean95% CIPMean95% CIPMean95% CIP
CEE only (reference)1050.650.59-0.712.582.29-2.861.931.65-2.20
CEE + MPA cyclic1030.590.53-0.640.142.862.53-3.190.202.271.95-2.600.11
CEE + MPA continuous1130.600.55-0.650.212.582.30-2.860.991.981.71-2.250.79
CEE + microP1070.690.63-0.740.373.182.80-3.550.012.492.13-2.850.01
Estrogen + progestogen groups combined3230.620.59-0.660.452.872.68-3.060.092.242.06-2.430.06
B. Baseline, 12 mo, and change in E1 (pg/mL) by treatment arm
nBaseline
12 mo
Change (12 mo − baseline)


Mean
95% CI
P
Mean
95% CI
P
Mean
95% CI
P
CEE only (reference)10515.814.3-17.3118105-13010289.0-115
CEE + MPA cyclic10315.314.1-16.60.6511198.3-1240.4695.683.0-1080.49
CEE + MPA continuous11316.114.6-17.60.7511098.4-1210.3793.882.5-1050.35
CEE + microP10717.415.3-19.60.2110392.6-1140.0886.075.5-96.50.06
Estrogen + progestogen groups combined32316.315.3-17.30.58108101-1150.1791.885.2-98.40.15
C. Baseline, 12 mo, and change in E1S/E1 [nmol/L]/[nmol/L] by treatment arm
nBaseline
12 mo
Change (12 mo − baseline)


Mean
95% CI
P
Mean
95% CI
P
Mean
95% CI
P
CEE only (reference)10535.932.0-39.918.517.0-20.0−17.4−21.7 to −13.1
CEE + MPA cyclic10331.726.9-36.60.1921.920.0-23.80.01−9.9−15.0 to −4.80.03
CEE + MPA continuous11332.929.9-35.90.2220.218.2-22.20.19−12.7−16.0 to −9.50.09
CEE + microP10736.332.6-40.00.8925.423.1-27.80.0000−11.2−14.9 to −7.50.03
Estrogen + progestogen groups combined32333.631.4-35.90.3222.521.2-23.70.0001−11.3−13.6 to −9.00.01
  • NOTE: P value is for the two-sample t test for the null hypothesis that the mean value for the listed treatment group is equal to the mean value of the CEE-alone treatment group.

    Abbreviation: 95% CI, 95% confidence interval.