Table 3.

Postmenopausal hormone therapy use and risk of breast cancer: E+P use main effect

Cases, n* (%)Controls, n* (%)OR (95% CI)
Years of E+P use
    Never150 (49.0)382 (62.6)1.0 (Reference)
    1-<1078 (25.5)127 (20.8)1.5 (1.0-2.2)
    10 or more78 (25.5)101 (16.6)1.9 (1.3-2.8)
Ptrend0.0002
  • * The numbers do not add up to the total number of cases and controls due to missing information.

  • Adjusted for age at baseline (<55, 55-<65, ≥65 y), race (White, other), body mass index (<25.0 kg/m2, 25.0-<30.0 kg/m2, ≥30.0 kg/m2, unknown), cigarette smoking (never, former, current, unknown), number of first-degree relatives with history of breast cancer (none, 1, 2+, unknown), prior breast biopsy (no, yes), and age at menopause (≤44, 45-49, ≥50 y, unknown).