Table 2.

Genetic variation and risk of postmenopausal breast cancer: genotype main effects

GenePolymorphism (SNP ID)*GenotypeCases, n (%)Controls, n (%)OR (95% CI)
COMTVal108/158Met (rs4680)Met/Met81 (28.4)148 (24.9)1.0 (Reference)
Met/Val or Val/Val204 (71.6)446 (75.1)0.8 (0.6-1.1)
CYP1A1Ile462Val (rs1048943)Ile/Ile291 (91.8)584 (92.3)1.0 (Reference)
Ile/Val or Val/Val26 (8.2)49 (7.7)1.1 (0.7-1.8)
CYP1A1MspI (rs4646903)T/T258 (80.9)495 (77.7)1.0 (Reference)
T/C or C/C61 (19.1)142 (22.3)0.8 (0.6-1.1)
CYP17A15′UTR (rs743572)A/A103 (32.1)231 (35.6)1.0 (Reference)
A/G or G/G218 (67.9)417 (64.4)1.2 (0.9-1.6)
CYP19A1Arg264Cys (rs700519)Arg/Arg292 (91.3)598 (93.1)1.0 (Reference)
Arg/Cys or Cys/Cys28 (8.8)44 (6.9)1.3 (0.8-2.1)
CYP19A13′UTR (rs10046)C/C73 (23.0)163 (25.4)1.0 (Reference)
C/T or T/T245 (77.0)479 (74.6)1.1 (0.8-1.6)
CYP1B1Arg48Gly (rs10012)Arg/Arg165 (52.4)334 (52.4)1.0 (Reference)
Arg/Gly or Gly/Gly150 (47.6)304 (47.6)1.0 (0.8-1.3)
CYP1B1Val432Leu (rs1056836)Leu/Leu104 (32.5)222 (34.4)1.0 (Reference)
Leu/Val or Val/Val216 (67.5)423 (65.6)1.1 (0.8-1.5)
CYP1B1Asn453Ser (rs1800440)Asn/Asn207 (64.9)427 (66.4)1.0 (Reference)
Asn/Ser or Ser/Ser112 (35.1)216 (33.6)1.1 (0.8-1.4)
ESR1Ser10Ser (rs2077647)T/T86 (26.9)176 (27.4)1.0 (Reference)
C/T + T/T234 (73.1)467 (72.6)1.0 (0.8-1.4)
GSTP1Ile105Val (rs1695)Ile/Ile141 (43.9)270 (41.7)1.0 (Reference)
Ile/Val or Val/Val180 (56.1)377 (58.3)0.9 (0.7-1.2)
PGR+331G/A (rs10895068)G/G294 (91.0)580 (89.2)1.0 (Reference)
G/A or A/A29 (9.0)70 (10.8)0.8 (0.5-1.3)
PGRVal660Leu (rs1042838)Val/Val218 (67.9)467 (72.5)1.0 (Reference)
Leu/Val or Leu/Leu103 (32.1)177 (27.5)1.3 (0.9-1.7)
SHBG5′UTR (rs1799941)G/G175 (54.7)374 (58.0)1.0 (Reference)
G/A or A/A145 (45.3)271 (42.0)1.1 (0.9-1.5)
SHBGAsp356Asn (rs6259)Asp/Asp256 (79.5)509 (78.5)1.0 (Reference)
Asp/Asn or Asn/Asn66 (20.5)139 (21.5)0.9 (0.7-1.3)
SULT1A1Arg213His (rs9282861)Arg/Arg158 (49.4)300 (46.9)1.0 (Reference)
Arg/His or His/His162 (50.6)340 (53.1)0.9 (0.7-1.2)
  • Abbreviations: OR, odds ratio; 95% CI, 95% confidence interval.

  • * dbSNP build 127, http://www.ncbi.nlm.nih.gov/projects/SNP/.

  • The numbers do not add up to the total number of cases and controls due to missing data on genotypes for some participants.

  • Adjusted for age at baseline (<55, 55-<65, ≥65 y) and race (White, other).