Table 3.

Multivariate-adjusted ORs for recurrence of any colorectal adenoma or advanced colorectal adenoma for quartile of IGF-I and IGFBP-3 serum concentrations controlling for each other

OR (95% CI)* for 1-Unit Change in Blood Variable
P trend
Q1Q2Q3Q4
IGF-I (ng/mL) at T0 (controlling for IGFBP-3)<110110-131132-159≥160
    Any adenoma (N = 370 cases)1.00 (reference)0.91 (0.59-1.42)0.66 (0.40-1.07)0.67 (0.39-1.14)0.07
    Advanced adenoma (N = 109cases)1.00 (reference)1.06 (0.47-2.41)0.71 (0.29-1.73)0.74 (0.26-2.08)0.40
IGFBP-3 (ng/mL) at T0 (controlling for IGF-I)<3,3773,377-3,9363,937-4,421≥4,422
    Any adenoma (N = 370 cases)1.00 (reference)0.62 (0.39-0.98)0.68 (0.41-1.13)0.77 (0.45-1.30)0.49
    Advanced adenoma (N = 109 cases)1.00 (reference)0.34 (0.13-0.86)0.38 (0.12-1.16)0.35 (0.13-0.93)0.09
IGF-I/IGFBP-3 Ratio at T0<0.0290.029-0.0340.035-0.040≥0.041
    Any adenoma (N = 370 cases)1.00 (reference)0.78 (0.47-1.17)1.03 (0.65-1.64)0.70 (0.42-1.16)0.44
    Advanced adenoma (N = 109 cases)1.00 (reference)0.61 (0.25-1.50)0.87 (0.36-2.08)0.79 (0.30-2.07)0.97
  • * All models adjust for age gender, BMI, control vs intervention randomization group, aspirin use, smoking, ethnicity, and education.