Table 2.

Age-adjusted and multivariate-adjusted ORs for recurrence of any colorectal adenoma or advanced colorectal adenoma by quartile of IGF-I and IGFBP-3 serum concentrations

OR (95% CI)*
Ptrend
Q1Q2Q3Q4
IGF-I (ng/mL) at T0<110110-131132-159≥160
    Any adenoma (n = 370 cases)
        Age and gender adjusted1.00 (reference)0.91 (0.60-1.39)0.65 (0.42-1.02)0.67 (0.42-1.05)0.03
        Multivariate adjusted1.00 (reference)0.90 (0.59-1.39)0.64 (0.41-1.01)0.65 (0.41-1.01)0.02
    Advanced adenoma (n = 109 cases)
        Age and gender adjusted1.00 (reference)0.89 (0.41-1.91)0.56 (0.25-1.26)0.50 (0.21-1.15)0.06
        Multivariate adjusted1.00 (reference)0.98 (0.44-2.19)0.60 (0.25-1.42)0.51 (0.21-1.29)0.09
IGFBP-3 (ng/mL) at T0<3,3773,377-3,9363,937-4,421≥4,422
    Any adenoma (n = 370 cases)
        Age and gender adjusted1.00 (reference)0.59 (0.38-0.91)0.63 (0.39-1.01)0.67 (0.43-1.06)0.14
        Multivariate adjusted1.00 (reference)0.58 (0.38-0.91)0.62 (0.38-1.01)0.66 (0.42-1.05)0.14
    Advanced adenoma (n = 109 cases)
        Age and gender adjusted1.00 (reference)0.40 (0.17-0.93)0.36 (0.13-0.98)0.36 (0.15-0.86)0.04
        Multivariate adjusted1.00 (reference)0.33 (0.13-0.83)0.35 (0.12-1.01)0.32 (0.13-0.82)0.04
  • * All models adjust for age and gender, and multivariate models additionally adjust for BMI, control vs intervention randomization group, aspirin use, smoking, ethnicity, and education.