Table 5.

Association between individual flavanone, flavonol, and isoflavonoid consumption and colorectal adenoma recurrence among participants during the PPT (n = 1,859)

QuartileRangesNo recurrence
Advanced recurrence
Any recurrence
ControlsCasesOR (95% CI)CasesOR (95% CI)
123736
Flavanones
    Hesperetin
        1<6.13*300221.001641.00
        26.14-13.98284261.15 (0.63-2.11)1811.14 (0.86-1.49)
        313.99-25.35262381.89 (1.07-3.33)2031.40 (1.07-1.84)
        4>25.35277371.66 (0.94-2.95)1881.16 (0.88-1.53)
        Ptrend0.030.14
    Naringenin
        1<2.93301241.001631.00
        22.93-5.72283271.18 (0.66-2.13)1821.18 (0.90-1.55)
        35.73-10.47282381.59 (0.90-2.80)1831.17 (0.88-1.54)
        4>10.47257341.52 (0.84-2.77)2081.46 (1.09-1.95)
        Ptrend0.110.02
Flavonols
    Isorhamnetin
        1<0.15290361.001741.00
        20.15-0.28266371.12 (0.68-1.87)1991.26 (0.96-1.65)
        3>0.28-0.46278351.02 (0.60-1.74)1871.16 (0.88-1.55)
        4>0.46289150.44 (0.21-0.90)1761.11 (0.81-1.53)
        Ptrend0.070.60
    Kaempferol
        1<2.69274351.001901.00
        22.69-4.73284411.07 (0.65-1.77)1810.90 (0.68-1.17)
        34.75-8.63274300.83 (0.47-1.46)1911.00 (0.75-1.33)
        4>8.64291170.44 (0.22-0.89)1740.91 (0.66-1.25)
        Ptrend0.030.73
    Myricetin
        1<0.35278281.001861.00
        20.35-0.54279401.57 (0.93-2.67)1861.06 (0.81-1.38)
        3>0.54-0.89278281.10 (0.62-1.93)1871.05 (0.80-1.38)
        4>0.89288271.01 (0.57-1.77)1771.01 (0.77-1.32)
        Ptrend0.670.98
    Quercetin
        1<4.12292341.001721.00
        24.12-5.88249451.55 (0.93-2.58)2161.60 (1.21-2.12)
        35.89-7.92291250.68 (0.36-1.27)1741.11 (0.82-1.51)
        4>7.92291190.59 (0.29-1.20)1741.23 (0.88-1.73)
        Ptrend0.040.71
Isoflavonoids
    Biochanin A
        1<0.027283361.001811.00
        20.027-0.050269340.90 (0.53-1.52)1961.08 (0.82-1.42)
        3>0.050-0.084276340.87 (0.50-1.52)1891.03 (0.77-1.38)
        4>0.084295190.50 (0.25-1.04)1700.95 (0.69-1.33)
        Ptrend0.110.75
    Daidzein
        1<0.0012290371.001741.00
        20.0012-0.0019265371.09 (0.66-1.81)2001.20 (0.91-1.57)
        30.0020-0.0030285380.78 (0.45-1.37)1801.05 (0.79-1.39)
        4>0.0030283210.62 (0.32-1.17)1821.13 (0.83-1.53)
        Ptrend0.100.64
    Formononetin
        1<0.0004275391.001891.00
        20.0004-0.0007279380.87 (0.53-1.42)1860.90 (0.68-1.18)
        30.0007-0.0011283250.61 (0.34-1.10)1820.92 (0.70-1.23)
        4>0.0011286210.49 (0.26-0.95)1790.94 (0.69-1.29)
        Ptrend0.020.76
    Genistein
        1<0.016283401.001811.00
        20.016-0.028271410.93 (0.57-1.51)1941.04 (0.79-1.36)
        3>0.028-0.046278240.55 (0.31-0.99)1871.04 (0.78-1.38)
        4>0.046291180.38 (0.19-0.76)1740.98 (0.71-1.35)
        Ptrend0.0030.93
  • NOTE: All models were adjusted for age, sex, body mass index, dietary fiber consumption, and regular NSAID use. Adenomatous polyp recurrence (any or advanced) was diagnosed through postintervention at year 4.

  • * Average daily individual flavanone, flavonol, and isoflavonoid intakes (in mg) are for the first 3 y of the PPT and were energy-adjusted by dividing through total caloric intake in 1,000 kcal (4.184 MJ).

  • Reference category.