Table 4.

Association between total flavonoid and flavonoid subgroup consumption and colorectal adenoma recurrence among participants during the PPT (n = 1,859)

QuartileRangeNo recurrence
Advanced recurrence
Any recurrence
ControlsCasesOR (95% CI)CasesOR (95% CI)
123736
Total flavonoids
    1<50.87*293301.001711.00
    250.87-76.12269361.32(0.76-2.27)1961.27(0.96-1.68)
    376.21-106.0283270.97(0.54-1.76)1821.14(0.85-1.53)
    4>106.0278301.15(0.64-2.07)1871.25(0.93-1.67)
    Ptrend0.940.27
Anthocyanins
    1<5.70289311.001751.00
    25.70-10.06265321.13(0.64-1.98)2001.27(0.96-1.69)
    310.07-15.58281301.06(0.57-1.95)1841.17(0.86-1.59)
    4>15.58288301.13(0.57-2.25)1771.13(0.80-1.60)
    Ptrend0.800.65
Flavan-3-ols
    1<10.22273351.001911.00
    210.23-17.22273351.05 (0.62-1.80)1921.03 (0.78-1.36)
    317.30-38.57292300.92 (0.53-1.60)1730.89 (0.67-1.18)
    4>38.57285230.65 (0.37-1.15)1800.94 (0.71-1.23)
    Ptrend0.120.44
Flavanones
    1<10.57305201.001591.00
    210.79-21.97281341.74 (0.96-3.15)1841.21 (0.92-1.59)
    322.00-36.86280371.39 (0.75-2.57)1851.21 (0.92-1.60)
    4>36.87257422.32 (1.28-4.20)2081.48 (1.11-1.96)
    Ptrend0.020.01
Flavones
    1<0.46277361.001871.00
    20.46-0.73285290.79 (0.45-1.37)1800.97 (0.73-1.28)
    3>0.73-1.10286270.84 (0.46-1.55)1791.05 (0.77-1.42)
    4>1.10275311.08 (0.55-2.10)1901.18 (0.84-1.66)
    Ptrend0.820.31
Flavonols
    1<8.12277391.001871.00
    28.12-12.01263400.97 (0.58-1.62)2021.19 (0.91-1.57)
    312.03-17.30294310.61 (0.34-1.10)1710.89 (0.66-1.20)
    4>17.30289130.24 (0.11-0.53)1760.96 (0.68-1.36)
    Ptrend0.00060.47
Isoflavonoids
    1<0.045286371.001781.00
    20.045-0.079261411.04(0.63-1.72)2041.17(0.90-1.54)
    3>0.079-0.133286260.59(0.33-1.06)1790.96(0.72-1.29)
    4>0.133290190.46(0.22-0.95)1751.02(0.74-1.42)
    Ptrend0.010.81
  • All models were adjusted for age, sex, body mass index, dietary fiber consumption, and regular NSAID use. Adenomatous polyp recurrence (any or advanced) was diagnosed through postintervention at year 4.

  • * Average daily total flavonoid and individual flavonoid intakes (in mg) are for the first 3 y of the PPT and were energy-adjusted by dividing through total caloric intake in 1,000 kcal (4.184 MJ).

  • Reference category.