Table 1.

ORs for postmenopausal breast cancer by Gc genotype in the vitamin D binding protein

Gc genotypeCases
Controls
Crude model*
Adjusted model 1
Adjusted model 2
n (%)n (%)OR (95% CI)OR (95% CI)OR (95% CI)
1,4022,608
Gc1s-1s472 (33.7)837 (32.1)111
Gc1s-1f255 (18.2)450 (17.2)1.00 (0.83-1.21)1.00 (0.82-1.22)1.05 (0.83-1.32)
Gc1f-1f39 (2.8)65 (2.5)1.07 (0.71-1.61)1.00 (0.65-1.52)1.03 (0.62-1.70)
Gc2-1s433 (30.9)844 (32.4)0.92 (0.78-1.08)0.90 (0.76-1.07)0.86 (0.71-1.05)
Gc2-1f117 (8.3)216 (8.3)0.96 (0.75-1.24)0.96 (0.74-1.25)0.85 (0.63-1.15)
Gc2-286 (6.1)196 (7.5)0.79 (0.60-1.04)0.72§ (0.54-0.96)0.76 (0.54-1.07)
Ptrend = 0.04
Gc1-1766 (54.7)1,352 (51.8)111
Gc2-1550 (39.2)1,060 (40.7)0.93 (0.81-1.06)0.91 (0.79-1.05)0.85 (0.72-1.00)
Gc2-286 (6.1)196 (7.5)0.79 (0.60-1.03)0.72§ (0.54-0.95)0.75 (0.54-1.04)
Gc2-1/2-20.91 (0.79-1.03)0.88 (0.77-1.01)0.84§ (0.72-0.98)
Ptrend = 0.02
  • * Conditional logistic regression stratified by year of birth.

  • Conditional logistic regression stratified by year of birth adjusted for age at menopause, first-degree family history of breast cancer, history of benign breast disease, number of pregnancies (≥28th wk), age at menarche, breast-feeding history, total number of mammograms, use of hormone therapy, body mass index, education level, and smoking status.

  • Adjustment as in model 1 with additional stratification by time of blood collection and additional adjustment on 25(OH)D status as continuous variable; 25(OH)D status was available only for 1,391 cases and 1,365 controls.

  • § P < 0.05.