Table 4.

Pharmacokinetic variables derived from pharmacokinetic model of curcumin conjugates

Mean ± SE95% confidence interval95% prediction interval
AUC (μg·h/mL), 10 g dose35.33 ± 3.7826.90-43.7510.62-117.01
AUC (μg·h/mL), 12 g dose26.57 ± 2.9719.96-33.187.86-89.46
Cmax (μg/mL), 10 g dose2.30 ± 0.261.72-2.880.71-7.04
Cmax (μg/mL), 12 g dose1.73 ± 0.191.30-2.160.52-5.41
Tmax (h)3.29 ± 0.432.34-4.241.56-7.37
t1/2 (h)6.77 ± 0.834.82-8.713.19-14.46
ka (h−1)1.05 ± 0.260.47-1.64NA
ke (h−1)0.08 ± 0.00500.069-0.091NA
v3.54 ± 0.412.63-4.46NA
Lag (h)0.68 ± 0.0160.64-0.71NA
Dose (g)−2.48 ± 0.98−4.66 to −0.30NA
  • NOTE: The mean ± SE of the estimate, 95% confidence intervals for the variable estimates, and 95% prediction intervals for the population are presented.

    Abbreviations: Cmax, peak concentration; Tmax, time of peak concentration; t1/2, half-life; ka, absorption constant; ke, excretion constant; v, bioavailability/volume; Lag, absorption lag; NA, not available.