Table 3.

The fraction of curcumin glucuronide and curcumin sulfate in plasma at Cmax after administration of 10 and 12 g curcumin based on enzymatic hydrolysis done in duplicate

Dose (g)Curcumin glucuronide (μg/mL)Curcumin sulfate (μg/mL)Total curcumin
Separate assay (μg/mL)Mixed assay (μg/mL)
102.04 ± 0.31*1.06 ± 0.403.10 ± 0.603.09 ± 0.53
121.40 ± 0.740.87 ± 0.442.27 ± 1.172.03 ± 0.74
  • NOTE: Total curcumin in plasma was assayed after incubating plasma with enzymes β-glucuronidase and sulfatase separately (separate assay) and combined (mixed assay).

  • * Mean ± SD of six subjects.