Table 4.

Prostate cancer risk associated with multiple SNPs demonstrating independent effects, by race

SNP*OR (95% CI)
Caucasians
rs979200
    GG1.00 (Reference)
    AG + AA0.77 (0.65-0.90)
rs1016343
    CC1.00 (Reference)
    CT + TT1.27 (1.07-1.52)
rs6983561
    AA1.00 (Reference)
    AC + CC1.55 (1.13-2.13)
rs7837328
    GG1.00 (Reference)
    AG + AA1.23 (1.03-1.46)
rs10090154
    CC1.00 (Reference)
    CT + TT1.41 (1.16-1.72)
African Americans
rs13254738
    AA1.00 (Reference)
    AC + CC2.99 (1.05-8.48)
rs6983561
    AA1.00 (Reference)
    AC + CC2.26 (1.04-4.94)
rs7000448
    CC1.00 (Reference)
    CT + TT3.4 (1.33-8.70)
  • * These SNPs were retained in stepwise selection models.

  • ORs are adjusted for age at diagnosis (cases) or reference (controls) date.

  • P < 0.00005 for both likelihood ratio–based tests comparing the full models containing five SNPs (Caucasian) or containing three SNPs (African American) with the reduced models adjusted only for age.