LA | hc2 | P | ||||||||
---|---|---|---|---|---|---|---|---|---|---|

Estimate (%) | 95% CI | Estimate (%) | 95% CI | |||||||

QC Pathology ≥CIN3 (n = 285) | ||||||||||

Sensitivity | 93.3 | 89.8-95.9 | 92.6 | 89.0-95.4 | 1 | |||||

Specificity | 48.1 | 46.3-49.9 | 50.6 | 48.8-52.4 | 0.05 | |||||

PPV | 14.6 | 13.0-16.3 | 15.1 | 13.4-16.9 | <0.0001 | |||||

NPV | 98.70 | 97.98-99.22 | 98.64 | 97.92-99.15 | 0.4 | |||||

Referral | 55.5 | 53.7-57.2 | 53.2 | 51.5-54.9 | 0.001 | |||||

CC Pathology ≥CIN2 (n = 354) | ||||||||||

Sensitivity | 87.8 | 83.9-91.1 | 91.0 | 87.5-93.8 | 0.09 | |||||

Specificity | 50.4 | 48.1-52.7 | 53.1 | 50.8-55.4 | 0.007 | |||||

PPV | 24.8 | 22.4-27.3 | 26.5 | 24.0-29.2 | <0.0001 | |||||

NPV | 95.68 | 94.20-96.87 | 96.93 | 95.67-97.91 | 0.8 | |||||

Referral | 55.6 | 53.5-57.7 | 53.9 | 51.7-56.0 | 0.04 |

NOTE: Differences in sensitivity, specificity, and referral were tested for statistical significance using an exact McNemar's χ

^{2}test. Statistical differences in PPV and NPV were determined by a method developed by Leisenring et al. (36), a score statistic derived from a marginal regression model and bears some relation to McNemar's statistic.