Table 3.

Prostate cancer risk associated with individual SNPs in the 8q24 region, by race

Caucasians
SNPCases,*n = 1,308 (%)Controls,*n = 1,266 (%)OR (95% CI)P
rs17398660, chr8:126113619
    GG1,038 (82.8)1,036 (84.0)1.00 (Reference)
    AG205 (16.4)185 (15.0)1.11 (0.89-1.38)
    AA10 (0.8)12 (9.7)0.83 (0.36-1.93)0.58
rs3860845, chr8:126152376
    TT529 (42.0)530 (42.8)1.00 (Reference)
    CT579 (46.0)556 (44.9)1.04 (0.88-1.24)
    CC152 (12.1)153 (12.4)1.00 (0.77-1.28)0.88
rs2384921,§ chr8:126156760
    CC458 (64.2)452 (63.9)1.00 (Reference)
    CT227 (32.1)227 (32.1)1.00 (0.8-1.26)
    TT28 (4.0)28 (4.0)0.88 (0.51-1.54)0.90
Ptrend = 0.80
rs979200, chr8:127992902
    GG576 (45.6)493 (39.7)1.00 (Reference)
    AG534 (42.3)599 (48.3)0.76 (0.64-0.90)
    AA153 (12.1)149 (12.0)0.88 (0.68-1.14)0.0062
rs1456310, chr8:128121615
    CC464 (37.0)401 (32.5)1.00 (Reference)
    CT598 (47.7)605 (49.1)0.85 (0.72-1.02)
    TT192 (15.3)227 (18.4)0.73 (0.58-0.92)0.024
Ptrend = 0.006
rs6470494, chr8:128157086 (Region 2)
    CC605 (47.9)659 (53.2)1.00 (Reference)
    CT515 (40.8)494 (39.9)1.14 (0.96-1.34)
    TT143 (11.3)85 (6.9)1.83 (1.37-2.45)0.0002
Ptrend = 0.0002
rs1016343, chr8:128162479 (Region 2)
    CC711 (56.7)796 (64.6)1.00 (Reference)
    CT454 (36.2)385 (31.2)1.32 (1.12-1.57)
    TT88 (7.0)52 (4.2)1.91 (1.33-2.73)<0.00005
Ptrend < 0.00005
rs13254738, chr8:128173525 (Region 2)
    AA571 (45.5)581 (47.1)1.00 (Reference)
    AC535 (42.6)543 (44.0)1.00 (0.85-1.18)
    CC150 (11.9)110 (8.9)1.37 (1.05-1.82)0.046
Ptrend = 0.08
rs6983561, chr8:128176062 (Region 2)
    AA1,124 (88.9)1,156 (93.5)1.00 (Reference)
    AC135 (10.7)78 (6.3)1.78 (1.33-2.39)
    CC5 (0.4)2 (0.2)2.50 (0.48-12.93)0.0002
Ptrend < 0.00005
rs16901966, chr8: 128179434 (Region 2)
    AA1,161 (89.2)1,179 (93.6)1.00 (Reference)
    AG136 (10.4)79 (6.3)1.75 (1.31-2.34)
    GG5 (0.4)2 (0.2)2.47 (0.48-12.75)0.0003
Ptrend = 0.0001
rs13281615, chr8:128424800
    AA426 (34.0)436 (35.3)1.00 (Reference)
    AG633 (50.5)568 (46.0)1.14 (0.96-1.36)
    GG195 (15.6)230 (18.6)0.87 (0.69-1.09)0.038
rs16902124, chr8:128426400
    GG1,132 (90.2)1,132 (91.8)1.00 (Reference)
    AG120 (9.6)97 (7.9)1.24 (0.94-1.65)
    AA3 (0.2)4 (0.3)0.73 (0.16-3.29)0.28
rs10505476, chr8:128477298 (Region 3)
    GG662 (52.7)705 (57.2)1.00 (Reference)
    AG513 (40.8)438 (35.5)1.25 (1.06-1.48)
    AA81 (6.5)90 (7.3)0.96 (0.70-1.32)0.022
rs10808555, chr8:128478693 (Region 3)
    AA531 (42.3)559 (45.4)1.00 (Reference)
    AG569 (45.4)540 (43.9)1.11 (0.94-1.31)
    GG154 (12.3)132 (10.7)1.23 (0.95-1.60)0.22
Ptrend = 0.08
rs6983267, chr8:128482487 (Region 3)
    GG364 (28.9)313 (25.3)1.00 (Reference)
    GT652 (51.8)617 (49.8)0.91 (0.75-1.10)
    TT242 (19.2)308 (24.9)0.67 (0.54-0.85)0.0017
    Ptrend = 0.0008
rs7837328, chr8:128492309 (Region 3)
    GG387 (30.8)451 (36.4)1.00 (Reference)
    AG639 (50.8)590 (47.6)1.26 (1.06-1.50)
    AA232 (18.4)198 (16.0)1.37 (1.08-1.73)0.0088
Ptrend = 0.003
rs7000448, chr8:128510352 (Region 3)
    CC494 (39.1)505 (40.8)1.00 (Reference)
    CT614 (48.7)568 (45.8)1.11 (0.94-1.31)
    TT154 (12.2)166 (13.4)0.95 (0.74-1.22)0.33
rs1447295, chr8:128554220 (Region 1)
    CC937 (74.8)994 (80.6)1.00 (Reference)
    AC288 (23.0)225 (18.3)1.36 (1.12-1.65)
    AA27 (2.2)14 (1.1)2.08 (1.07-3.95)0.0012
Ptrend = 0.0002
rs10090154, chr8:128601319 (Region 1)
    CC968 (75.2)1007 (80.6)1.00 (Reference)
    CT294 (22.8)230 (18.4)1.33 (1.09-1.61)
    TT26 (2.0)13 (1.0)2.09 (1.07-4.10)0.0019
Ptrend = 0.0005
rs7837688, chr8:128608542 (Region 1)
    GG945 (75.0)1005 (81.0)1.00 (Reference)
    GT287 (22.8)222 (17.9)1.37 (1.13-1.67)
    TT28 (2.2)14 (1.1)2.14 (1.12-4.10)0.0006
Ptrend = 0.0001
rs7824074, chr8:128658004
    GG620 (49.1)646 (52.1)1.00 (Reference)
    GT544 (43.1)496 (40.0)1.14 (0.97-1.35)
    TT99 (7.8)99 (8.0)1.04 (0.77-1.40)0.28
rs3891248, chr8:128819321 (MYC)
    TT921 (74.3)871 (70.6)1.00 (Reference)
    AT299 (24.1)330 (26.8)0.86 (0.72-1.03)
    AA19 (1.5)32 (2.6)0.55 (0.31-0.98)0.041
Ptrend = 0.02
rs4645959, chr8:128819722 (MYC)
    AA1178 (93.4)1158 (93.5)1.00 (Reference)
    AG81 (6.4)80 (6.5)1.00 (0.73-1.38)
    GG2 (0.2)01.00
African Americans
SNP
Cases,* n = 149 (%)
Controls,* n = 85 (%)
OR (95% CI)
P
rs17398660, chr8:126113619
    GG138 (96.5)74 (93.7)1.00 (Reference)
    AG + AA5 (3.5)5 (6.3)0.57 (0.15-2.23)0.42
rs3860845, chr8:126152376
    TT5 (3.4)3 (3.8)1.00 (Reference)
    CT + CC140 (96.6)76 (96.2)1.75 (0.36-8.50)0.49
rs2384921,§ chr8:126156760
    CC73 (70.2)46 (75.4)1.00 (Reference)
    CT + TT31 (29.8)15 (24.6)1.50 (0.69-3.28)0.3
rs979200, chr8:127992902
    GG16 (11.1)7 (8.9)1.00 (Reference)
    AG + AA128 (88.9)72 (91.1)0.94 (0.35-2.56)0.91
rs1456310, chr8:128121615
    CC21 (14.6)19 (24.1)1.00 (Reference)
    CT + TT123 (85.4)60 (75.9)2.36 (1.11-5.02)0.025
rs6470494, chr8:128157086 (Region 2)
    CC90 (62.1)44 (56.4)1.00 (Reference)
    CT + TT55 (37.9)34 (43.6)0.85 (0.47-1.54)0.59
rs1016343, chr8:128162479 (Region 2)
    CC90 (62.9)45 (57.0)1.00 (Reference)
    CT + TT53 (37.1)34 (43.0)0.74 (0.41-1.35)0.33
rs13254738, chr8:128173525 (Region 2)
    AA9 (6.3)16 (20.3)1.00 (Reference)
    AC + CC135 (93.8)63 (79.7)4.18 (1.64-10.65)0.002
rs6983561, chr8:128176062 (Region 2)
    AA22 (15.2)32 (41.0)1.00 (Reference)
    AC + CC123 (84.8)46 (59.0)4.01 (2.02 (7.97))0.0001
rs16901966, chr8: 128179434 (Region 2)
    AA52 (35.4)46 (56.1)1.00 (Reference)
    AG + GG95 (64.6)36 (43.9)2.24 (1.25-4.02)0.0062
rs13281615, chr8:128424800
    AA44 (30.6)22 (27.9)1.00 (Reference)
    AG + GG100 (69.4)57 (72.2)0.77 (0.40-1.46)0.42
rs16902124, chr8:128426400
    GG114 (80.9)66 (84.6)1.00 (Reference)
    AG + AA27 (19.1)12 (15.2)1.32 (0.60-2.90)0.49
rs10505476, chr8:128477298 (region 3)
    GG15 (10.4)12 (15.2)1.00 (Reference)
    AG + AA129 (89.6)67 (84.8)1.86 (0.76-4.53)0.17
rs10808555, chr8:128478693 (region 3)
    AA46 (31.9)27 (34.2)1.00 (Reference)
    AG + GG98 (68.1)52 (65.8)1.19 (0.64-2.21)0.57
rs6983267, chr8:128482487 (region 3)
    GG122 (84.1)59 (75.6)1.00 (Reference)
    GT + TT23 (15.9)19 (24.4)0.57 (0.28-1.18)0.13
rs7837328, chr8:128492309 (region 3)
    GG17 (11.7)13 (16.5)1.00 (Reference)
    AG + AA128 (88.3)66 (83.5)1.91 (0.81-4.50)0.14
rs7000448, chr8:128510352 (region 3)
    CC10 (7.4)17 (22.7)1.00 (Reference)
    CT + TT125 (92.6)58 (77.3)3.62 (1.47-8.91)0.0042
rs1447295, chr8:128554220 (Region 1)
    CC64 (44.4)36 (45.6)1.00 (Reference)
    AC + AA80 (55.6)43 (54.4)1.19 (0.66-2.14)0.57
rs10090154, chr8:128601319 (Region 1)
    CC85 (58.2)54 (67.5)1.00 (Reference)
    CT + TT61 (41.8)26 (32.5)1.69 (0.92-3.11)0.22
rs7837688, chr8:128608542 (Region 1)
    GG115 (79.3)67 (85.9)1.00 (Reference)
    GT + TT30 (20.7)11 (14.1)1.69 (0.77-3.73)0.18
rs7824074, chr8:128658004
    GG104 (71.7)56 (71.8)1.00 (Reference)
    GT + TT41 (28.3)22 (28.2)1.17 (0.61-2.24)0.64
rs3891248, chr8:128819321 (MYC)
    TT23 (15.9)16 (20.5)1.00 (Reference)
    AT + AA122 (84.1)62 (79.5)1.66 (0.70-3.96)0.44
rs4645959, chr8:128819722 (MYC)
    AA143 (98.6)78 (98.7)1.00 (Reference)
    AG + GG2 (1.4)1 (1.3)2.11 (0.18-24.17)0.54
  • * Total number of cases and controls varies by SNP due to missing genotype data.

  • ORs are adjusted for age at diagnosis (cases) or reference date (controls).

  • Nominal P values based on a likelihood ratio test.

  • § Genotyping in study I was unsuccessful for this SNP.