Table 2.

Clinical performance of carcinogenic HPV detection by LA and hc2 for enrollment ≥CIN3 as diagnosed by QC Pathology and ≥CIN2 as diagnosed by clinical center pathologists in women referred into ALTS for an ASCUS Pap and restricted to women participating in the IC arm (n = 1,089)

Estimate (%)95% CIEstimate (%)95% CI
QC Pathology ≥CIN3 (n = 55)
CC Pathology ≥CIN2 (n = 113)
  • NOTE: Differences in sensitivity, specificity, and referral were tested for statistical significance using an exact McNemar's χ2 test. Statistical differences in PPV and NPV were determined by a method developed by Leisenring et al. (36), a score statistic derived from a marginal regression model and bears some relation to McNemar's statistic.