Table 1.

Comparison of and agreement for detection of carcinogenic HPV by LA and hc2 for all paired tests, stratified by cytologic interpretations, by hc2 status (negative, positive), and by log units of hc2 signal strength (RLU/CO), semiquantitative measure of viral load, for women referred into ALTS for an ASCUS Pap

nhc2+n(%)LA+n(%)LA-/hc2-n(%)LA-/hc2+n(%)LA+/hc2-n(%)LA+/hc2+n(%)% Agreement% Positive agreementκP
All hc23,2891,749 (53)
All LA3,4461,914 (56)
All pairs3,2891,749 (53)1,824 (55)1,238 (38)227 (7)302 (9)1,522 (46)84740.680.001
Cytology negative1,535465 (30)580 (38)862 (56)93 (6)208 (14)372 (24)80550.57<0.0001
Cytology positive (≥ASCUS)1,7071,266 (74)1,222 (72)354 (21)131 (8)87 (5)1,135 (66)87840.680.003
ASCUS822456 (55)465 (57)295 (36)62 (8)71 (9)394 (48)84750.670.4
LSIL581535 (92)493 (85)37 (6)51 (9)9 (2)484 (83)90890.50<0.0001
HSIL (including ASC-H)304275 (90)264 (87)22 (7)18 (6)7 (2)257 (85)92910.590.03
hc2+ (1.00-9.99 RLU/CO)409287 (70)122 (30)287 (70)
hc2+ (10.00-99.99 RLU/CO)478418 (87)60 (13)418 (87)
hc2+ (100.00-999.99 RLU/CO)621582 (94)39 (6)582 (94)
hc2+ (≥1,000 RLU/CO)241235 (98)6 (2)235 (98)
  • NOTE: Differences were tested for statistical significance using an exact McNemar's χ2 test.