Table 5.

Association between MTHFR C667T and A1298C diplotypes and risk of glioma

HistologyMTHFR diplotype 677_1298Cases (%)Controls (%)OR (95% CI)PORPdiplotype
AllCC_AA133 (13.3)167 (16.6)Reference0.02
CC_AC261 (26.0)196 (19.4)1.68 (1.25-2.25)0.0006
CC_CC96 (9.6)102 (10.1)1.18 (0.82-1.69)0.36
CT_AA219 (21.9)242 (24.0)1.14 (0.85-1.52)0.40
CT_AC195 (19.5)199 (19.7)1.23 (0.91-1.66)0.18
TT_AA97 (9.7)102 (10.1)1.19 (0.83-1.71)0.34
TT_AC1 (0.10)1 (0.10)
CT_CC00
TT_CC00
CC_AA133 (13.3)167 (16.6)Reference0.02
CT/TT_AA316 (31.5)344 (34.1)1.15 (0.87-1.52)0.31
CC_AC/CC357 (35.6)298 (29.5)1.51 (1.14-1.98)0.004
CT/TT_AC/CC196 (19.6)200 (19.8)1.23 (0.91-1.66)0.18
GlioblastomaCC_AA52 (11.7)167 (16.6)Reference0.01
CC_AC121 (27.1)196 (19.4)2.01 (1.37-2.96)0.0004
CC_CC38 (8.5)102 (10.1)1.21 (0.74-1.97)0.44
CT_AA97 (21.7)242 (24.0)1.31 (0.89-1.94)0.18
CT_AC87 (19.5)199 (19.7)1.43 (0.96-2.14)0.08
TT_AA50 (11.2)102 (10.1)1.57 (0.99-2.50)0.05
TT_AC1 (0.2)1 (0.10)
CT_CC00
TT_CC00
CC_AA52 (11.7)167 (16.6)Reference0.02
CT/TT_AA159 (35.7)344 (34.1)1.39 (0.96-2.00)0.08
CC_AC/CC147 (33.0)298 (29.5)1.74 (1.20-2.51)0.0032
CT/TT_AC/CC88 (19.7)200 (19.8)1.44 (0.96-2.15)0.08
AstrocytomaCC_AA56 (17.0)167 (16.6)Reference0.86
CC_AC75 (22.8)196 (19.4)1.15 (0.77-1.72)0.50
CC_CC32 (9.7)102 (10.1)0.94 (0.57-1.55)0.80
CT_AA74 (22.5)242 (24.0)0.90 (0.61-1.35)0.62
CT_AC64 (19.5)199 (19.7)0.96 (0.63-1.45)0.83
TT_AA28 (8.5)102 (10.1)0.80 (0.48-1.35)0.41
TT_AC01 (0.10)
CT_CC00
TT_CC00
CC_AA56 (17.0)167 (16.6)Reference0.63
CT/TT_AA107 (32.5)344 (34.1)0.87 (0.60-1.27)0.49
CC_AC/CC102 (31.0)298 (29.5)1.08 (0.74-1.57)0.70
CT/TT_AC/CC64 (19.5)200 (19.8)0.95 (0.63-1.44)0.82
OligodendrogliomaCC_AA11 (10.4)167 (16.6)Reference0.13
CC_AC32 (30.2)196 (19.4)2.56 (1.24-5.26)0.01
CC_CC10 (9.4)102 (10.1)1.44 (0.59-3.54)0.42
CT_AA20 (18.9)242 (24.0)1.17 (0.54-2.51)0.69
CT_AC22 (20.8)199 (19.7)1.57 (0.73-3.34)0.25
TT_AA11 (10.4)102 (10.1)1.48 (0.62-3.55)0.38
TT_AC01 (0.10)
CT_CC00
TT_CC00
CC_AA11 (10.4)167 (16.6)Reference0.07
CT/TT_AA42 (39.6)344 (34.1)1.26 (0.62-2.58)0.52
CC_AC/CC31 (29.2)298 (29.5)2.16 (1.08-4.33)0.03
CT/TT_AC/CC22 (20.8)200 (19.8)1.56 (0.73-3.32)0.25