Table 2.

Risks of meningioma associated with folate metabolism polymorphisms

Gene and SNPGenotypeCases (%)Controls (%)OR (95% CI)Ptrend
MTHFR
A1298C (rs1801131)AA277 (44.0)310 (48.7)1.00 (reference)0.59
AC297 (47.1)253 (39.7)1.32 (1.04-1.66)*
CC56 (8.9)74 (11.6)0.85 (0.58-1.24)
AC + CC353 (56.0)327 (51.3)1.21 (0.97-1.51)
C677T (rs1801133)CC262 (41.5)306 (48.0)1.00 (reference)0.08
CT304 (48.2)265 (41.6)1.35 (1.07-1.71)*
TT65 (10.3)66 (10.4)1.16 (0.79-1.70)
CT + TT369 (58.5)331 (52.0)1.31 (1.05-1.64)*
MTRR
A66G (rs1801394)AA201 (31.9)236 (37.0)1.00 (reference)0.03
AG308 (48.8)299 (46.9)1.21 (0.94-1.55)
GG122 (19.3)102 (16.0)1.41 (1.02-1.94)*
AG + GG430 (68.1)401 (63.0)1.26 (1.00-1.59)*
MTR
A2756G (rs1805087)AA411 (65.1)401 (63.1)1.00 (reference)0.52
AG195 (30.9)210 (33.0)0.91 (0.71-1.15)
GG25 (4.0)25 (3.9)0.98 (0.55-1.73)
AG + GG220 (34.9)235 (36.9)0.91 (0.73-1.15)