Table 1.

Genotype counts, minor allele frequencies, and Hardy-Weinberg equilibrium P values for folate metabolism-related polymorphisms in meningioma and glioma cases and controls in the five series

Gene and SNPStudy centerMeningioma
Glioma
CasesControlsMAFHWECasesControlsMAFHWE
MTHFR
A1298C (rs1801131)AAACCCAAACCCAAACCCAAACCC
UK-North8073209464170.280.2617416233203130360.270.04
UK-Southeast545986248130.300.4098941910985200.290.62
Sweden6177116466190.350.728886239182230.330.52
Denmark445795343170.340.103651124545100.331.00
Finland38318373280.310.795464106454130.310.84
C677T (rs1801131)CCCTTTCCCTTTCCCTTTCCCTTT
UK-North5798197378240.360.7416816041155168460.401.00
UK-Southeast5057144860150.370.7084992787105210.380.23
Sweden6468178257100.261.00110701710377170.310.60
Denmark4555105645120.310.5164341613450.231.00
Finland46265472550.230.526551126057140.361.00
MTRR
A66G (rs1801394)AAAGGGAAAGGGAAAGGGAAAGGG
UK-North5483377478230.350.7411517778128179620.491.00
UK-Southeast4157233959250.440.8569974566101470.580.49
Sweden3984265374220.400.736894356697340.511.00
Denmark4147224055180.401.00425074037230.540.02
Finland2637143033140.400.353969204370180.470.28
MTR
A2756G (rs1805087)AAAGGGAAAGGGAAAGGGAAAGGG
UK-North1135471066080.221.0025610113240115130.191.00
UK-Southeast77395754260.221.0013174612975100.221.00
Sweden98456945140.200.441226781335770.180.81
Denmark73334704030.200.5667293702550.180.17
Finland50243561740.160.1074495824540.200.59
  • Abbreviations: MAF, minor allele frequency in controls; HWE, Hardy-Weinberg equilibrium exact test P value.