Table 4.

Relative risk for colorectal cancer for strata of aspirin assignment, BMI, and period by quartile of dietary n-3 fatty acid intake from fish

Dietary intake of n-3 fatty acids from fish
Ptrend
Quartile 1
Quartile 2
Quartile 3
Quartile 4
Cases/person-yearsRR (95% CI)Cases/person-yearsRR (95% CI)Cases/person-yearsRR (95% CI)Cases/person-yearsRR (95% CI)
Aspirin
    No73/46,3581.00 (Ref)78/49,8241.00 (0.73-1.38)53/46,4880.72 (0.50-1.02)55/45,2950.79 (0.55-1.12)*0.08
    Yes64/45,3291.00 (Ref)61/49,8520.85 (0.60-1.21)65/46,7940.92 (0.65-1.30)51/46,2330.72 (0.50-1.05)*0.12
BMI
    <2569/53,7281.00 (Ref)71/57,0940.99 (0.71-1.38)55/54,5490.77 (0.54-1.10)59/53,9250.85 (0.60-1.21)0.24
    ≥2568/37,9581.00 (Ref)68/42,5830.89 (0.64-1.25)63/38,7330.87 (0.62-1.23)47/37,6030.68 (0.47-0.98)0.04
Period
Before 199579/53,7291.00 (Ref)72/58,0660.87 (0.64-1.20)67/54,3690.82 (0.59-1.13)72/53,6560.89 (0.65-1.23)0.54
1995 or later58/43,1261.00 (Ref)67/47,2081.03 (0.72-1.47)51/44,1390.82 (0.56-1.20)34/43,2630.58 (0.38-0.89)0.005
  • Abbreviation: Ref, reference.

  • * Adjusted for the same covariates as the multivariate model in Table 2 except random assignment to aspirin or placebo (Pinteraction = 0.83).

  • Adjusted for the same covariates as the multivariate model in Table 2 except BMI (Pinteraction = 0.14).

  • Adjusted for the same covariates as the multivariate model in Table 2 (Pinteraction = 0.18).