Table 5.

Summary of haplotype-specific effects and global test for a multiplicative effect in the group of strong smokers

Haplotype numberSNP6SNP7SNP8SNP9SNP10SNP11Exp(β)P
MMP1_010000100.940.952
MMP1_021010100.880.901
MMP1_031011011.160.880
MMP1_041001111.120.911
MMP1_051011111.490.692
MMP1_061111111.580.651
Allele 1CATCCG
Allele 0TGCTTA
Robust score test0.049*
  • NOTE: SNP coded as 0 for minor allele and 1 for major allele. Exp(β), haplotype effect estimate (positive values are indicating a risk increasing effect). Boldfaced data indicate risk increasing effect in single SNP association analyses.

  • * P < 0.05.