Table 2.

Conditional logistic regression analysis of lung cancer with SNPs in the MMP1 gene

ModelMAF (%)
All cases and controls
Strong smokers (≥20 pack-years)
Never and weak smokers (<20 pack-years)
ControlsCasesPOR (95% CI)POR (95% CI)POR (95% CI)
SNP6: rs996999 (1831 C>T)2019
    General0.16541.5 (0.8-2.6)0.1951.6 (0.8-3.1)0.57241.3 (0.5-3.5)
0.0332*1.8 (1.0-3.1)0.0498*1.9 (1.0-3.7)0.34921.6 (0.6-4.0)
    F-statistics0.0459*(Padjust = 0.1182)
    Dominant0.05421.7 (1.0-2.9)0.07511.8 (0.9-3.4)0.40491.5 (0.6-3.7)
    Recessive0.0376*1.3 (1.0-1.6)0.07021.3 (1.0-1.7)0.28831.2 (0.8-1.8)
    Multiplicative0.0152*1.3 (1.0-1.5)0.0314*1.3 (1.0-1.6)0.2361.2 (0.9-1.7)
SNP9: rs1938901 (7229 C>T)3128
    General0.05341.5 (1.0-2.2)0.0238*1.79 (1.1-3.0)0.78951.1 (0.6-2.0)
0.00331.8 (1.2-2.7)0.00162.23 (1.4-3.7)0.43471.3 (0.7-2.3)
    F-statistics0.0089(Padjust = 0.01821)
    Dominant0.00961.7 (1.1-2.4)0.00392.02 (1.3-3.3)0.57021.2 (0.7-2.1)
    Recessive0.0156*1.3 (1.1-1.6)0.0208*1.39 (1.1-1.8)0.32511.2 (0.8-1.7)
    Multiplicative0.00271.3 (1.1-1.5)0.00231.39 (1.1-1.7)0.31741.1 (0.9-1.5)
SNP11: rs193008 (12471 G>A)3128
    General0.06031.5 (1.0-2.2)0.0409*1.7 (1.0-2.8)0.63571.2 (0.6-2.1)
0.00411.8 (1.2-2.6)0.00292.14 (1.3-3.5)0.36131.3 (0.7-2.4)
    F-statistics0.0108*(Padjust = 0.02334)
    Dominant0.0117*1.6 (1.1-2.4)0.00751.93 (1.2-3.1)0.46021.6 (0.7-2.2)
    Recessive0.0173*1.3 (1.0-1.6)0.0208*1.39 (1.1-1.8)0.35541.2 (0.8-1.7)
    Multiplicative0.00321 (1.1-1.5)0.00311.38 (1.1-1.7)0.30111.2 (0.9-1.5)
  • NOTE: Data are matched for age and gender. All ORs are adjusted for smoking. Padjust, P values adjusted for multiple testing. SNP position is counted in basepairs to/from start (AUG); risk allele is in boldface. F-statistics was used for the full model versus the model without any genetic effect. The table shows only the polymorphisms with significant association results; the entire results can be seen in Supplementary Table S3.

    Abbreviation: MAF, minor allele frequency.

  • * P < 0.05.

  • P < 0.01.