Table 1.

Demographic and tumor characteristics by tumor detection method

VariableScreen detected (n = 2,387), n (%)Symptom detected (n = 3,094), n (%)Total (n = 5,481), n (%)P
Age at diagnosis (y)
    40-49572 (24.0)1,129 (36.5)1,701 (31.0)
    50-59834 (34.9)1,067 (34.5)1,901 (34.7)
    ≥60981 (41.1)898 (29.0)1,879 (34.3)<0.001
Race
    White1,903 (79.7)2,206 (71.3)4,109 (75.0)
    African American199 (8.3)342 (11.1)541 (9.9)
    Other285 (12.0)546 (17.6)831 (15.1)<0.001
Tumor stage
    I1,432 (60.0)779 (25.2)2,211 (40.3)
    II813 (34.1)1,541 (49.8)2,354 (43.0)
    III125 (5.2)660 (21.3)785 (14.3)
    IV17 (0.7)114 (3.7)131 (2.4)<0.001
Tumor size
    T016 (0.7)38 (1.3)54 (1.0)
    T11,817 (76.3)1,221 (39.7)3,038 (55.7)
    T2444 (18.7)1,192 (38.8)1,636 (30.0)
    T3-T4103 (4.3)622 (20.2)725 (13.3)
    Unknown72128<0.001
Nodal status
    Negative1,684 (70.6)1,594 (51.7)3,278 (59.9)
    Positive700 (29.4)1,492 (48.3)2,192 (40.1)
    Unknown3811<0.001
Nuclear grade
    Well/moderately differentiated1,453 (62.1)1,329 (44.3)2,782 (52.1)
    Poorly differentiated885 (37.9)1,669 (55.7)2,554 (47.9)
    Unknown4996145<0.001
Lymphatic/vascular invasion
    No1,995 (84.3)2,261 (74.9)4,256 (79.0)
    Yes372 (15.7)758 (25.1)1,130 (21.0)
    Unknown207595<0.001
ER status
    Negative432 (19.0)975 (32.7)1,407 (26.8)
    Positive1,839 (81.0)2,004 (67.3)3,843 (73.2)
    Unknown116115231<0.001
PR status
    Negative768 (34.0)1,267 (42.8)2,035 (39.0)
    Positive1,492 (66.0)1,692 (57.2)3,184 (61.0)
    Unknown127135262<0.001
HER-2/neu immunohistochemistry score
    0 or 1+1,280 (75.6)1,433 (66.9)2,713 (70.7)
    2+201 (11.9)319 (14.9)520 (13.6)
    3+212 (12.5)390 (18.2)602 (15.7)
    Unknown6949521,646<0.001
Ki-67 proliferation
    <10%307 (30.1)216 (17.2)523 (23.0)
    10-30%518 (50.7)574 (45.7)1,092 (48.0)
    >30%196 (19.2)465 (37.1)661 (29.0)
    Unknown1,3661,8393,205<0.001
Surgery and radiation
    Breast-conserving surgery alone111 (4.7)134 (4.3)245 (4.5)
    Breast-conserving surgery + radiation1,208 (50.6)1,114 (36.0)2,322 (42.4)
    Mastectomy alone827 (34.6)935 (30.2)1,762 (32.1)
    Mastectomy + radiation226 (9.5)841 (27.2)1,067 (19.5)
    None15 (0.6)70 (2.3)85 (1.5)<0.001
Adjuvant chemotherapy
    No1,515 (63.5)1,659 (53.6)3,174 (57.9)
    Yes872 (36.5)1,435 (46.4)2,307 (42.1)<0.001
Adjuvant endocrine therapy
    No765 (32.0)1,260 (40.7)2,025 (36.9)
    Yes1,622 (68.0)1,834 (59.3)3,456 (63.1)<0.001
Neoadjuvant chemotherapy
    No2,102 (88.1)1,896 (61.3)3,998 (72.9)
    Yes285 (11.9)1,198 (38.7)1,483 (27.1)<0.001
    Total2,387 (43.5)3,094 (56.5)5,481 (100.0)