Table 4.

Association between any NSAID use and change in mammographic density between two screening mammograms* stratified by age at first mammogram, Group Health, 1996-2006

<65 y
≥65 y
Increase vs stay dense, OR (95% CI)*Decrease vs stay dense, OR (95% CI)*Stay not dense vs stay dense, OR (95% CI)*Increase vs stay dense, OR (95% CI)*Decrease vs stay dense, OR (95% CI)*Stay not dense vs stay dense, OR (95% CI)*
Nonuser1.001.001.001.001.001.00
Initiator1.04 (0.90-1.19)1.12 (0.96-1.30)1.24 (1.12-1.36)1.05 (0.90-1.22)1.06 (0.89-1.25)1.02 (0.92-1.14)
Discontinuer0.93 (0.70-1.23)1.09 (0.82-1.45)1.00 (0.83-1.22)1.14 (0.82-1.59)1.51 (1.08-2.11)1.22 (0.97-1.54)
Continuer1.23 (0.85-1.80)1.07 (0.69-1.65)1.48 (1.14-1.93)1.09 (0.78-1.51)1.01 (0.69-1.48)1.18 (0.93-1.48)
Mixed1.30 (0.88-1.92)1.38 (0.91-2.09)1.29 (0.97-1.71)0.96 (0.65-1.41)0.75 (0.46-1.21)0.99 (0.75-1.30)
  • * Adjusted for BMI at first mammogram, HRT use, and time between the two mammograms.