Table 3.

Association between type of NSAIDS and change in mammographic density between two screening mammograms, Group Health, 1996-2006

Stay dense
Increase
Decrease
Stay not dense
nnOR (95% CI)*OR (95% CI)nOR (95% CI)*OR (95% CI)nOR (95% CI)*OR (95% CI)
Nonuser7,8112,3661.001.001,8821.001.008,5941.001.00
Initiators
    Any NSAID1,9216871.13 (1.02-1.25)1.03 (0.93-1.14)5411.14 (1.02-1.27)1.09 (0.97-1.21)2,8291.26 (1.18-1.34)1.12 (1.04-1.20)
    Nonprescription1,5735761.14 (1.02-1.26)1.05 (0.94-1.17)4491.14 (1.01-1.28)1.11 (0.98-1.25)2,3311.22 (1.13-1.31)1.11 (1.03-1.20)
    Prescription4701711.15 (0.96-1.38)1.03 (0.85-1.24)1391.18 (0.97-1.43)1.08 (0.88-1.32)7251.30 (1.15-1.46)1.11 (0.97-1.26)
Discontinuers
    Any NSAID3791261.07 (0.87-1.32)1.00 (0.81-1.23)1251.35 (1.10-1.67)1.24 (1.00-1.54)5261.22 (1.07-1.40)1.08 (0.93-1.25)
    Nonprescription279971.14 (0.90-1.44)1.08 (0.85-1.38)1001.48 (1.17-1.87)1.40 (1.10-1.79)3841.21 (1.03-1.42)1.12 (0.94-1.32)
    Prescription109310.91 (0.61-1.36)0.77 (0.51-1.15)291.05 (0.70-1.59)0.88 (0.57-1.35)1551.22 (0.95-1.57)0.96 (0.74-1.25)
Continuers
    Any NSAID235971.25 (0.98-1.58)1.09 (0.85-1.41)671.13 (0.85-1.49)1.02 (0.76-1.35)4391.50 (1.27-1.76)1.25 (1.05-1.49)
    Nonprescription160651.21 (0.90-1.62)1.10 (0.81-1.48)511.25 (0.91-1.73)1.19 (0.85-1.65)3201.56 (1.28-1.89)1.40 (1.13-1.72)
    Prescription78331.33 (0.88-2.00)1.10 (0.72-1.66)180.93 (0.56-1.56)0.72 (0.42-1.24)1201.29 (0.97-1.72)0.93 (0.69-1.27)
Mixed type
    Any NSAID194841.35 (1.04-1.75)1.07 (0.81-1.41)591.22 (0.91-1.64)1.03 (0.75-1.40)3221.39 (1.16-1.67)1.08 (0.89-1.32)
    Nonprescription170821.94 (1.31-2.87)1.64 (1.08-2.48)531.36 (0.85-2.18)1.11 (0.67-1.83)2971.24 (0.92-1.67)1.06 (0.77-1.46)
    Prescription134500.66 (0.41-1.06)0.58 (0.35-0.96)380.88 (0.51-1.53)0.88 (0.50-1.57)2381.26 (0.90-1.76)1.07 (0.75-1.54)
  • * Adjusted for age at first mammogram.

  • Adjusted for age at first mammogram, BMI at first mammogram, HRT use, and time between the two mammograms.

  • Mixed-type includes individuals who may have initiated one type of NSAID while discontinuing another or continued one type of NSAID while initiating or discontinuing another.