Table 2.

Pooled RRs and 95% CIs for ovarian cancer according to height, the Pooling Project of Prospective Studies of Diet and Cancer

Height per 5 cm incrementP for between studies-heterogeneityHeight, categorical (m)
PtrendP for between studies-heterogeneity*
All females
<1.601.60 to <1.651.65 to <1.70≥1.70
    n cases455570571440
    Age-adjusted RR (95% CI)1.10 (1.05-1.15)0.151 (Reference)1.06 (0.94-1.20)1.17 (1.03-1.33)1.38 (1.17-1.64)<0.0010.15
    Multivariate adjusted RR,,§ (95% CI)1.10 (1.05-1.15)0.131 (Reference)1.06 (0.94-1.21)1.18 (1.04-1.34)1.38 (1.16-1.65)<0.0010.14
Postmenopausal females (at baseline)
    n cases314372377273
    Age-adjusted RR (95% CI)1.07 (1.02-1.13)0.251 (Reference)1.01 (0.87-1.18)1.13 (0.97-1.32)1.23 (1.04-1.46)0.0060.47
    Multivariate adjusted RR,,§ (95% CI)1.07 (1.02-1.13)0.211 (Reference)1.02 (0.87-1.19)1.14 (0.98-1.34)1.25 (1.04-1.49)0.0040.42
Premenopausal females (at diagnosis)
    n cases29324344
    Age-adjusted RR (95% CI)1.20 (1.05-1.37)0.431 (Reference)0.90 (0.53-1.53)1.16 (0.66-2.04)1.79 (1.07-2.97)0.010.58
    Multivariate adjusted RR (95% CI)1.20 (1.05-1.37)0.481 (Reference)0.92 (0.54-1.59)1.20 (0.67-2.13)1.79 (1.07-3.00)0.0090.62
All females, serous carcinoma**
    n cases201275293215
    Age-adjusted RR (95% CI)1.12 (1.06-1.18)0.321 (Reference)1.12 (0.93-1.35)1.30 (1.07-1.57)1.43 (1.17-1.75)<0.0010.57
    Multivariate adjusted RR,,§ (95% CI)1.13 (1.06-1.20)0.221 (Reference)1.14 (0.95-1.37)1.33 (1.10-1.60)1.47 (1.20-1.81)<0.0010.53
All females, endometrioid carcinoma**,††
    n cases49746367
    Age-adjusted RR (95% CI)1.18 (1.05-1.32)0.291 (Reference)1.25 (0.86-1.80)1.15 (0.78-1.69)1.75 (1.18-2.60)0.0020.87
    Multivariate adjusted RR,,§ (95% CI)1.18 (1.06-1.32)0.331 (Reference)1.28 (0.88-1.86)1.21 (0.82-1.78)1.76 (1.18-2.64)0.0020.90
All females, mucinous carcinoma**,‡‡
    n cases30323028
    Age-adjusted RR (95% CI)1.07 (0.92-1.25)0.321 (Reference)0.21 (0.48-1.37)0.09 (0.49-1.63)1.12 (0.64-1.94)0.350.55
    Multivariate adjusted RR,,§ (95% CI)1.05 (0.90-1.22)0.511 (Reference)0.85 (0.51-1.44)0.89 (0.49-1.61)1.12 (0.64-1.94)0.420.61
  • * Based on the highest category versus the reference category.

  • Multivariate RRs were adjusted for age at menarche (<13, 13, >13 y), oral contraceptive use (ever, never), parity (0, 1, 2, >2), BMI (<23, 23-24.9, 25-29.9, >30 kg/m2), smoking status (never, past, current), physical activity (low, medium, high), and energy intake (continuously).

  • Multivariate RRs were also adjusted for menopausal status at baseline.

  • § Multivariate RRs were also adjusted for hormone replacement therapy use among postmenopausal women (never, past, current).

  • NHS II was not included in these analyses because this study has <10 cases and New York State Cohort was not included because this study had no information on menopausal status.

  • Only Canadian National Breast Screening Study, New York University Women's Health Study, NHSa, NHSb, and NHS II were included in the analyses because the other studies have <10 cases per study or had no premenopausal women included at baseline.

  • ** Adventist Health Study was not included in these analyses because information on histologic subtypes was not available.

  • †† New York State Cohort and New York University Women's Health Study were not included in these analyses because each study had <10 cases.

  • ‡‡ Breast Cancer Detection Demonstration Project Follow-up Study, NHS II, New York State Cohort, New York University Women's Health Study, and Women's Health Study were not included because each study had <10 cases.