Table 4.

Associations of SNP in PI3KCB gene with mammographic breast density according to IGF-I levels

Gene namers numberGenotypen (%)
Mean percent density (%)*
Mean absolute density (cm2)*
IGF-I
IGF-I
IGF-I
≤Median
>Median
≤Median
>Median
Pinteraction≤Median
>Median
Pinteraction
≤217.75
>217.75
≤217.75
>217.75
≤217.75
>217.75
(ng/mL)(ng/mL)(ng/mL)(ng/mL)(ng/mL)(ng/mL)
PI3KCBrs361072TT99 (13.5)100 (13.6)47.141.852.447.7
TC190 (25.9)183 (25.0)41.443.045.946.9
CC77 (10.5)84 (11.5)39.640.641.544.3
P†0.0090.700.110.0080.410.18

  • ↵* Analyses are adjusted for age, body mass index, waist-to-hip ratio, number of full-term pregnancies, number of breast biopsies, and smoking status. Mean absolute density is presented as back-transformed values.

  • ↵† P value for codominant model is the Ptrend for the test of gene dosages.