Table 1.

SNPs evaluated in the present study

Gene nameEncoded productnAlleles (major > minor)SNP reference ID*Position in geneCodonPanelCall rateDiseases or factors associated to SNP
IGF-IInsulin-like growth factor-I737A > Grs5742612PromoterSNPstream99.5%Colorectal cancer (18)
732C > Ars1549593Intron 3Sequenom98.8%Breast cancer (17); levels of IGF-I (17)
733C > Grs1520220Intron 3Sequenom98.9%Breast cancer (17); levels of IGF-I (17)
731A > Grs6220Exon 4; 3′-untranslated regionSNPstream98.7%Breast cancer (17); levels of IGF-I (17)
IGFBP-3Insulin-like growth factor–binding protein-3735G > Ars2132572PromoterSNPstream99.2%Breast cancer (17); levels of IGFBP-3 (17)
731A > Crs2854744PromoterSequenom98.7%Breast cancer (17, 19); breast density (23); levels of IGFBP-3 (17, 19)
733G > Crs2471551Intron 1Sequenom98.9%Breast cancer (19); levels of IGFBP-3 (17, 19)
736C > Trs3110697Intron 3SNPstream99.3%Breast cancer (19); levels of IGFBP-3 (19)
IGF1RInsulin-like growth factor receptor 1734G > Ars2229765Exon 16Glu1013GluSNPstream99.1%Levels of free IGF-I (20)
IRS1Insulin receptor substrate 1736G > Ars1801278Exon 1Gly972ArgSNPstream99.3%Colorectal cancer (22); prostate cancer (21)
PI3KCBPhosphoinositide-3-kinase, catalytic, β polypeptide733T > Crs361072PromoterSNPstream98.9%Levels of free IGF-I (20)