Table 2.

Associations between polymorphisms in multiple obesity-related genes and the risk of EAC, EGJAC, and ESCC and BMI

Locus descriptionGenotypeEAC
EGJAC
ESCC
BMI ≤25 kg/m2
BMI 25-29.9 kg/m2
BMI ≥30 kg/m2
BMI ≤25
BMI 25-29.9
BMI ≥30
BMI ≤25
BMI 25-29.9
BMI ≥30
OR* (95% CI)OR* (95% CI)OR* (95% CI)OR* (95% CI)OR* (95% CI)OR* (95% CI)OR* (95% CI)OR* (95% CI)OR* (95% CI)
rs1501299GG1.0 (reference)1.0 (reference)1.0 (reference)1.0 (reference)1.0 (reference)1.0 (reference)1.0 (reference)1.0 (reference)1.0 (reference)
ADIPOQGT0.52 (0.25-1.11)0.89 (0.56-1.43)0.69 (0.40-1.20)0.74 (0.42-1.30)1.25 (0.8-1.96)0.82 (0.48-1.41)0.92 (0.57-1.50)0.98 (0.55-1.74)1.05 (0.48-2.30)
IntronTT0.80 (0.31-2.03)0.22 (0.05-1.05)1.29 (0.54-3.12)1.46 (0.7-3.05)1.63 (0.67-3.98)0.52 (0.19-1.49)0.93 (0.30-2.85)1.01 (0.20-4.95)
rs2167270GG1.0 (reference)1.0 (reference)1.0 (reference)1.0 (reference)1.0 (reference)1.0 (reference)1.0 (reference)1.0 (reference)1.0 (reference)
LEPGA2.13 (0.98-4.63)1.92 (1.15-3.20)0.84 (0.49-1.45)1.39 (0.79-2.47)0.97 (0.60-1.54)0.92 (0.54-1.57)1.24 (0.76-2.03)0.85 (0.47-1.54)1.05 (0.48-2.30)
5′-UTRAA1.76 (0.59-5.25)1.87 (0.94-3.74)0.54 (0.22-1.33)1.53 (0.71-3.30)1.67 (0.92-3.03)1.03 (0.47-2.27)0.63 (0.28-1.41)1.08 (0.49-2.40)1.12 (0.33-3.84)
rs1137100 (K109R)AA1.0 (reference)1.0 (reference)1.0 (reference)1.0 (reference)1.0 (reference)1.0 (reference)1.0 (reference)1.0 (reference)1.0 (reference)
LEPRAG1.65 (0.82-3.34)1.03 (0.64-1.66)0.57 (0.33-0.98)1.22 (0.71-2.08)0.96 (0.61-1.49)0.85 (0.50-1.42)1.18 (0.73-1.89)0.81 (0.45-1.47)1.05 (0.48-2.30)
Nonsynonymous codingGG0.91 (0.19-4.42)2.20 (1.08-4.47)0.53 (0.19-1.50)0.58 (0.17-2.03)0.86 (0.34-2.21)0.75 (0.28-2.02)0.56 (0.20-1.56)0.78 (0.26-2.38)2.60 (0.90-7.50)
rs1137101 (Q223R)AA1.0 (reference)1.0 (reference)1.0 (reference)1.0 (reference)1.0 (reference)1.0 (reference)1.0 (reference)1.0 (reference)1.0 (reference)
LEPRAG1.56 (0.71-3.4)1.78 (1.03-3.05)0.74 (0.41-1.33)1.39 (0.77-2.53)1.25 (0.76-2.04)1.12 (0.62-2.03)1.05 (0.62-1.76)1.41 (0.74-2.68)1.05 (0.48-2.30)
Nonsynonymous codingGG1.10 (0.39-3.08)2.11 (1.09-4.10)0.48 (0.22-1.05)1.28 (0.60-2.74)1.67 (0.90-3.10)0.90 (0.43-1.87)0.89 (0.45-1.75)1.29 (0.56-2.96)1.05 (0.39-2.88)
rs8179183 (K656N)GG1.0 (reference)1.0 (reference)1.0 (reference)1.0 (reference)1.0 (reference)1.0 (reference)1.0 (reference)1.0 (reference)1.0 (reference)
LEPRGC1.73 (0.85-3.51)0.66 (0.39-1.12)1.64 (0.91-2.95)1.10 (0.62-1.94)0.86 (0.53-1.41)0.99 (0.55-1.76)1.16 (0.71-1.89)1.22 (0.67-2.22)1.05 (0.48-2.30)
Nonsynonymous codingCC1.95 (0.36-10.7)0.63 (0.18-2.24)2.43 (0.48-12.3)1.75 (0.52-5.88)1.44 (0.54-3.85)1.38 (0.29-6.59)0.99 (0.25-3.90)0.45 (0.06-3.52)5.33 (0.52-55.1)
rs1042571GG1.0 (reference)1.0 (reference)1.0 (reference)1.0 (reference)1.0 (reference)1.0 (reference)1.0 (reference)1.0 (reference)1.0 (reference)
POMCGA1.42 (0.70-2.89)0.76 (0.47-1.25)1.26 (0.72-2.20)0.83 (0.46-1.47)0.83 (0.52-1.33)1.13 (0.66-1.94)0.97 (0.59-1.60)0.94 (0.50-1.76)1.05 (0.48-2.30)
3′-UTRAA1.49 (0.30-7.43)1.50 (0.44-5.07)7.48 (1.31-42.6)0.95 (0.26-3.46)1.56 (0.54-4.48)3.50 (0.49-24.9)1.15 (0.35-3.73)3.14 (0.93-10.6)3.72 (0.30-46.8)
rs1800206 (L162V)CC1.0 (reference)1.0 (reference)1.0 (reference)1.0 (reference)1.0 (reference)1.0 (reference)1.0 (reference)1.0 (reference)1.0 (reference)
PPARαCG3.98 (1.85-8.57)0.76 (0.35-1.64)0.71 (0.30-1.71)1.12 (0.53-2.39)1.13 (0.59-2.15)0.56 (0.22-1.43)1.12 (0.59-2.15)1.30 (0.57-2.94)1.05 (0.48-2.30)
Nonsynonymous codingGG3.20 (0.26-39.8)1.54 (0.09-26.7)7.63 (1.02-57.3)1.24 (0.09-17.8)2.92 (0.22-39.0)
rs3856806 (H447H)CC1.0 (reference)1.0 (reference)1.0 (reference)1.0 (reference)1.0 (reference)1.0 (reference)1.0 (reference)1.0 (reference)1.0 (reference)
PPARγCT0.98 (0.43-2.25)0.94 (0.54-1.65)2.58 (1.41-4.72)0.95 (0.50-1.80)1.25 (0.76-2.05)1.65 (0.90-3.0)0.89 (0.50-1.60)1.12 (0.59-2.16)1.05 (0.48-2.30)
Synonymous codingTT9.45 (1.35-66.2)0.40 (0.04-3.63)4.81 (0.83-27.7)5.59 (0.90-34.8)1.22 (0.28-5.30)3.21 (0.33-31.3)1.15 (0.13-9.93)
rs1128977 (A140A)GG1.0 (reference)1.0 (reference)1.0 (reference)1.0 (reference)1.0 (reference)1.0 (reference)1.0 (reference)1.0 (reference)1.0 (reference)
RXRγGA1.29 (0.61-2.74)0.86 (0.53-1.41)0.59 (0.34-1.04)1.66 (0.92-2.99)1.41 (0.89-2.24)0.90 (0.53-1.54)1.16 (0.70-1.90)0.81 (0.44-1.49)1.05 (0.48-2.30)
Synonymous codingAA1.63 (0.62-4.32)1.11 (0.59-2.09)0.75 (0.35-1.58)1.84 (0.85-4.0)1.01 (0.52-1.96)0.66 (0.30-1.47)0.92 (0.46-1.87)1.18 (0.55-2.53)0.59 (0.15-2.30)
rs4684677 (L90Q)AA1.0 (reference)1.0 (reference)1.0 (reference)1.0 (reference)1.0 (reference)1.0 (reference)1.0 (reference)1.0 (reference)1.0 (reference)
GHRLAT0.70 (0.25-1.99)0.67 (0.30-1.52)1.09 (0.43-2.78)0.46 (0.17-1.25)0.83 (0.40-1.70)0.79 (0.33-1.89)0.65 (0.30-1.42)0.41 (0.12-1.38)1.05 (0.48-2.30)
Nonsynonymous codingTT12.68 (0.7-229)0.80 (0.08-8.38)
rs696217 (M72L)CC1.0 (reference)1.0 (reference)1.0 (reference)1.0 (reference)1.0 (reference)1.0 (reference)1.0 (reference)1.0 (reference)1.0 (reference)
GHRLCA3.26 (1.50-7.09)1.74 (0.96-3.14)1.01 (0.49-2.10)1.71 (0.83-3.55)0.86 (0.45-1.63)1.23 (0.62-2.44)1.03 (0.52-2.03)0.49 (0.17-1.42)1.05 (0.48-2.30)
Nonsynonymous codingAA3.82 (0.35-42.2)3.50 (0.31-39.2)1.32 (0.15-11.8)
rs7566605GG1.0 (reference)1.0 (reference)1.0 (reference)1.0 (reference)1.0 (reference)1.0 (reference)1.0 (reference)1.0 (reference)1.0 (reference)
INSIG2GC0.81 (0.39-1.67)0.73 (0.44-1.19)1.08 (0.61-1.89)0.88 (0.50-1.53)1.10 (0.69-1.73)1.0 (0.59-1.70)0.93 (0.58-1.51)1.58 (0.88-2.86)1.05 (0.48-2.30)
10 kb upstreamCC1.28 (0.46-3.60)0.82 (0.39-1.72)1.34 (0.53-3.38)0.57 (0.20-1.61)1.03 (0.51-2.09)0.72 (0.27-1.94)0.86 (0.38-1.94)0.93 (0.33-2.61)2.97 (1.0-8.97)
  • * ORs and 95% CIs adjusted for age (in years), sex, smoking, and frequency of gastroesophageal reflux symptoms.