Table 1.

Associations between polymorphisms in multiple obesity-related genes and risk of EAC, EGJAC, and ESCC

Locus descriptionGenotypeControl proportion (n = 1,352)EAC
EGJAC
ESCC
Proportion (n = 260)P*OR (95% CI)Proportion (n = 301)P*OR (95% CI)Proportion (n = 213)P*OR (95% CI)
rs1501299GG0.560.631.0 (reference)0.531.0 (reference)0.601.0 (reference)
ADIPOQGT0.370.340.75 (0.54-1.03)0.360.96 (0.72-1.29)0.340.89 (0.64-1.25)
IntronTT0.070.030.38 (0.17-0.83)0.101.50 (0.94-2.39)0.050.72 (0.36-1.43)
Minor allele0.260.200.0080.290.20.220.2
rs2167270GG0.400.361.0 (reference)0.381.0 (reference)0.401.0 (reference)
LEPGA0.460.501.41 (1.02-1.95)0.441.04 (0.77-1.39)0.491.09 (0.77-1.53)
5′-UTRAA0.130.131.21 (0.75-1.95)0.181.40 (0.94-2.08)0.120.87 (0.52-1.45)
Minor allele0.360.390.40.400.20.360.9
rs1137100 (K109R)AA0.530.521.0 (reference)0.531.0 (reference)0.541.0 (reference)
LEPRAG0.390.380.93 (0.67-1.27)0.421.0 (0.76-1.33)0.380.89 (0.64-1.25)
Nonsynonymous codingGG0.090.091.20 (0.70-2.05)0.050.72 (0.40-1.31)0.081.0 (0.55-1.80)
Minor allele0.280.290.80.260.30.270.5
rs1137101 (Q223R)AA0.310.281.0 (reference)0.271.0 (reference)0.301.0 (reference)
LEPRAG0.490.541.25 (0.88-1.76)0.531.28 (0.93-1.75)0.501.01 (0.70-1.45)
Nonsynonymous codingGG0.200.181.08 (0.69-1.68)0.201.30 (0.87-1.93)0.201.08 (0.68-1.70)
Minor allele0.440.450.90.460.30.451.0
rs8179183 (K656N)GG0.690.691.0 (reference)0.681.0 (reference)0.661.0 (reference)
LEPRGC0.280.281.12 (0.80-1.57)0.270.98 (0.72-1.33)0.321.16 (0.82-1.64)
Nonsynonymous codingCC0.030.031.09 (0.48-2.52)0.041.51 (0.77-2.96)0.020.91 (0.34-2.44)
Minor allele0.170.171.00.180.60.180.5
rs1042571GG0.660.651.0 (reference)0.671.0 (reference)0.641.0 (reference)
POMCGA0.310.311.05 (0.76-1.44)0.280.93 (0.69-1.25)0.311.09 (0.77-1.54)
3′-UTRAA0.030.042.08 (0.95-4.58)0.041.56 (0.76-3.22)0.041.85 (0.84-4.10)
Minor allele0.180.200.50.190.90.200.4
rs1800206 (L162V)CC0.880.871.0 (reference)0.881.0 (reference)0.851.0 (reference)
PPARαCG0.120.131.26 (0.81-1.98)0.110.96 (0.63-1.48)0.151.21 (0.77-1.92)
Nonsynonymous codingGG0.000.012.59 (0.34-19.7)0.013.42 (0.65-18.0)0.001.23 (0.12-12.8)
Minor allele0.060.070.60.061.00.080.4
rs3856806 (H447H)CC0.790.731.0 (reference)0.741.0 (reference)0.801.0 (reference)
PPARγCT0.200.251.36 (0.95-1.93)0.241.24 (0.90-1.71)0.191.03 (0.69-1.53)
Synonymous codingTT0.010.022.09 (0.74-5.94)0.021.58 (0.54-4.61)0.011.14 (0.24-5.28)
Minor allele0.110.150.040.140.10.110.8
rs1128977 (A140A)GG0.380.411.0 (reference)0.331.0 (reference)0.391.0 (reference)
RXRγGA0.460.420.81 (0.59-1.13)0.521.28 (0.95-1.72)0.460.98 (0.69-1.38)
Synonymous codingAA0.150.181.07 (0.70-1.64)0.141.06 (0.70-1.61)0.150.95 (0.59-1.53)
Minor allele0.390.391.00.410.30.381.0
rs4684677 (L90Q)AA0.880.911.0 (reference)0.901.0 (reference)0.901.0 (reference)
GHRLAT0.110.090.77 (0.46-1.29)0.090.70 (0.44-1.13)0.100.81 (0.48-1.37)
Nonsynonymous codingTT0.000.000.011.28 (0.23-7.03)0.00
Minor allele0.060.050.20.050.40.050.4
rs696217 (M72L)CC0.850.791.0 (reference)0.841.0 (reference)0.881.0 (reference)
GHRLCA0.140.211.69 (1.14-2.50)0.161.13 (0.77-1.66)0.110.81 (0.49-1.33)
Nonsynonymous codingAA0.010.000.000.43 (0.05-3.39)0.011.20 (0.26-5.62)
Minor allele0.080.100.050.080.60.060.5
rs7566605GG0.460.481.0 (reference)0.461.0 (reference)0.421.0 (reference)
INSIG2GC0.440.400.82 (0.59-1.13)0.450.98 (0.74-1.32)0.481.13 (0.81-1.58)
10 kb upstreamCC0.110.121.0 (0.61-1.65)0.090.81 (0.49-1.32)0.111.13 (0.66-1.94)
Minor allele0.320.320.90.320.70.340.5
  • * P control versus case comparison.

  • ORs and 95% CIs adjusted for age (in years), sex, smoking, BMI, and frequency of gastroesophageal reflux symptoms.