Table 1.

NNK in smokeless tobacco and saliva and total NNAL in the urine of smokeless tobacco users

SubjectNNK (pmol)*
Total NNAL (pmol)
(A) 2.0 g Tobacco before use*(B) Tobacco after use(C) Expectorated salivaDose = A - B - CExcreted in urine in 3 d after chewingTotal NNAL excreted as % of NNK dose
142,6006,2301,88034,5008782.54
242,60021,6003,62017,4003,10017.8
342,6005,0209,08028,5002,1007.37
442,60023,9004,30014,4001,49010.3
542,60035,4001,4005,8001,73029.8
642,60032,1008219,6801,32013.6
742,60021,8005,07015,7006,35040.4
842,60029,2006,5206,8801,28018.6
942,60017,9007,54017,2001,0706.22
1016,9006,5407210,3006826.62
1116,9004,730012,2002902.38
1216,9004,06059912,2009757.99
1316,9004,2301,57011,1006035.43
1416,9003,2001,85011,9001,72014.5
1516,9003,80072512,4001,26010.2
12.9 ± 10.4
  • * To convert to microgram, multiply by 207 × 10-6.

  • Different tobacco batches were used for subjects 1-9 and 10-15.