Table 2.

HR (95% CI) for exocrine pancreatic cancer according to energy-adjusted baseline daily intake of flavonoids in the ATBC Study (n = 27,111), 1985-2004

FlavonoidQuintiles of energy-adjusted intake (1 = lowest, 5 = highest)
Ptrend
1*2
3
4
5
HR (95% CI)HR (95% CI)HR (95% CI)HR (95% CI)
Total flavonoids
    Range of intake (mg)≤6.45>6.45-9.14>9.14-12.82>12.82-22.88>22.88
    No. cases/person-years71/72,24462/72,91051/74,82559/75,82363/75,860
    Multivariate adjusted10.88 (0.62-1.24)0.72 (0.50-1.03)0.84 (0.59-1.19)0.90 (0.64-1.28)0.98
Flavonols
    Range of intake (mg)≤5.24>5.24-6.98>6.98-9.09>9.09-13.00>13.00
    No. cases/person-years71/71,58567/72,89548/74,71057/76,18463/76,289
    Multivariate adjusted10.96 (0.68-1.34)0.68 (0.47-0.98)0.81 (0.57-1.16)0.91 (0.64-1.30)0.77
Kaempferol
    Range of intake (mg)≤0.20>0.20-0.34>0.34-0.61>0.61-1.94>1.94
    No. cases/person-years65/72,85361/72,60264/74,86555/75,72161/75,622
    Multivariate adjusted10.93 (0.66-1.33)0.94 (0.66-1.34)0.82 (0.57-1.19)0.93 (0.65-1.33)0.84
Myricetin
    Range of intake (mg)≤0.35>0.35-0.54>0.54-0.80>0.80-1.28>1.28
    No. cases/person-years63/72,62770/72,76551/74,65359/75,61763/76,001
    Multivariate adjusted11.10 (0.78-1.55)0.81 (0.56-1.17)0.93 (0.65-1.34)1.04 (0.73-1.49)0.88
Quercetin
    Range of intake (mg)≤4.44>4.44-5.86>5.86-7.44>7.44-9.87>9.87
    No. cases/person-years66/71,63965/72,65651/74,87457/75,77167/76,723
    Multivariate adjusted11.02 (0.72-1.43)0.78 (0.54-1.14)0.89 (0.62-1.28)1.07 (0.75-1.53)0.69
Flavan-3-ols
    Range of intake (mg)≤0.90>0.90-1.82>1.82-3.51>3.51-9.75>9.75
    No. cases/person-years66/73,71864/72,60064/74,29651/75,40361/75,646
    Multivariate adjusted10.96 (0.68-1.35)0.94 (0.66-1.34)0.76 (0.52-1.10)0.92 (0.64-1.31)0.72
Catechin
    Range of intake (mg)≤0.35>0.35-0.68>0.68-1.30>1.30-3.65>3.65
    No. cases/person-years61/73,57172/73,02660/74,62354/74,79959/75,644
    Multivariate adjusted11.15 (0.81-1.62)0.94 (0.65-1.34)0.86 (0.59-1.25)0.95 (0.66-1.36)0.56
Epicatechin
    Range of intake (mg)≤0.49>0.49-1.10>1.10-2.24>2.24-6.19>6.19
    No. cases/person-years68/73,82662/72,19959/74,67456/75,37761/75,587
    Multivariate adjusted10.91 (0.65-1.29)0.85 (0.60-1.21)0.82 (0.57-1.18)0.90 (0.63-1.28)0.83
Flavones
    Range of intake (mg)≤0.035>0.035-0.056>0.056-0.087>0.087-0.197>0.197
    No. cases/person-years63/73,85458/73,36769/73,33054/74,95962/76,152
    Multivariate adjusted10.91 (0.64-1.30)1.08 (0.76-1.52)0.82 (0.57-1.18)0.99 (0.70-1.42)0.99
Apigenin
    Range of intake (mg)≤0.016>0.016-0.029>0.029-0.046>0.046-0.121>0.121
    No. cases/person-years60/75,64168/74,37953/73,47761/72,45164/75,714
    Multivariate adjusted11.11 (0.78-1.57)0.84 (0.58-1.21)0.96 (0.67-1.37)1.06 (0.74-1.51)0.68
Luteolin
    Range of intake (mg)≤0.012>0.012-0.020>0.020-0.036>0.036-0.067>0.067
    No. cases/person-years61/72,76070/71,75057/73,79452/75,93666/77,422
    Multivariate adjusted11.14 (0.81-1.61)0.93 (0.64-1.33)0.86 (0.59-1.25)1.09 (0.77-1.56)0.82
  • * Reference category.

  • Multivariate-adjusted HRs are adjusted for age at randomization, years of smoking, total number of cigarettes per day, self-reported history of diabetes mellitus, and energy-adjusted saturated fat intake.