Table 2.

HR (95% CI) for exocrine pancreatic cancer according to energy-adjusted baseline daily intake of flavonoids in the ATBC Study (n = 27,111), 1985-2004

Flavonoid	Quintiles of energy-adjusted intake (1 = lowest, 5 = highest)
		1*	2	3	4	5
		1*		HR (95% CI)	HR (95% CI)	HR (95% CI)	HR (95% CI)
Total flavonoids
Range of intake (mg)	≤6.45	>6.45-9.14	>9.14-12.82	>12.82-22.88	>22.88
No. cases/person-years	71/72,244	62/72,910	51/74,825	59/75,823	63/75,860
Multivariate adjusted^†	1	0.88 (0.62-1.24)	0.72 (0.50-1.03)	0.84 (0.59-1.19)	0.90 (0.64-1.28)	0.98
Flavonols
Range of intake (mg)	≤5.24	>5.24-6.98	>6.98-9.09	>9.09-13.00	>13.00
No. cases/person-years	71/71,585	67/72,895	48/74,710	57/76,184	63/76,289
Multivariate adjusted	1	0.96 (0.68-1.34)	0.68 (0.47-0.98)	0.81 (0.57-1.16)	0.91 (0.64-1.30)	0.77
Kaempferol
Range of intake (mg)	≤0.20	>0.20-0.34	>0.34-0.61	>0.61-1.94	>1.94
No. cases/person-years	65/72,853	61/72,602	64/74,865	55/75,721	61/75,622
Multivariate adjusted	1	0.93 (0.66-1.33)	0.94 (0.66-1.34)	0.82 (0.57-1.19)	0.93 (0.65-1.33)	0.84
Myricetin
Range of intake (mg)	≤0.35	>0.35-0.54	>0.54-0.80	>0.80-1.28	>1.28
No. cases/person-years	63/72,627	70/72,765	51/74,653	59/75,617	63/76,001
Multivariate adjusted	1	1.10 (0.78-1.55)	0.81 (0.56-1.17)	0.93 (0.65-1.34)	1.04 (0.73-1.49)	0.88
Quercetin
Range of intake (mg)	≤4.44	>4.44-5.86	>5.86-7.44	>7.44-9.87	>9.87
No. cases/person-years	66/71,639	65/72,656	51/74,874	57/75,771	67/76,723
Multivariate adjusted	1	1.02 (0.72-1.43)	0.78 (0.54-1.14)	0.89 (0.62-1.28)	1.07 (0.75-1.53)	0.69
Flavan-3-ols
Range of intake (mg)	≤0.90	>0.90-1.82	>1.82-3.51	>3.51-9.75	>9.75
No. cases/person-years	66/73,718	64/72,600	64/74,296	51/75,403	61/75,646
Multivariate adjusted	1	0.96 (0.68-1.35)	0.94 (0.66-1.34)	0.76 (0.52-1.10)	0.92 (0.64-1.31)	0.72
Catechin
Range of intake (mg)	≤0.35	>0.35-0.68	>0.68-1.30	>1.30-3.65	>3.65
No. cases/person-years	61/73,571	72/73,026	60/74,623	54/74,799	59/75,644
Multivariate adjusted	1	1.15 (0.81-1.62)	0.94 (0.65-1.34)	0.86 (0.59-1.25)	0.95 (0.66-1.36)	0.56
Epicatechin
Range of intake (mg)	≤0.49	>0.49-1.10	>1.10-2.24	>2.24-6.19	>6.19
No. cases/person-years	68/73,826	62/72,199	59/74,674	56/75,377	61/75,587
Multivariate adjusted	1	0.91 (0.65-1.29)	0.85 (0.60-1.21)	0.82 (0.57-1.18)	0.90 (0.63-1.28)	0.83
Flavones
Range of intake (mg)	≤0.035	>0.035-0.056	>0.056-0.087	>0.087-0.197	>0.197
No. cases/person-years	63/73,854	58/73,367	69/73,330	54/74,959	62/76,152
Multivariate adjusted	1	0.91 (0.64-1.30)	1.08 (0.76-1.52)	0.82 (0.57-1.18)	0.99 (0.70-1.42)	0.99
Apigenin
Range of intake (mg)	≤0.016	>0.016-0.029	>0.029-0.046	>0.046-0.121	>0.121
No. cases/person-years	60/75,641	68/74,379	53/73,477	61/72,451	64/75,714
Multivariate adjusted	1	1.11 (0.78-1.57)	0.84 (0.58-1.21)	0.96 (0.67-1.37)	1.06 (0.74-1.51)	0.68
Luteolin
Range of intake (mg)	≤0.012	>0.012-0.020	>0.020-0.036	>0.036-0.067	>0.067
No. cases/person-years	61/72,760	70/71,750	57/73,794	52/75,936	66/77,422
Multivariate adjusted	1	1.14 (0.81-1.61)	0.93 (0.64-1.33)	0.86 (0.59-1.25)	1.09 (0.77-1.56)	0.82

↵* Reference category.
↵† Multivariate-adjusted HRs are adjusted for age at randomization, years of smoking, total number of cigarettes per day, self-reported history of diabetes mellitus, and energy-adjusted saturated fat intake.