Table 2.

Logistic regression analysis of rs6983267 and colon cancer

GenotypeCases (%)Controls (%)Crude
Age-adjusted*
Full model
OR (95% CI)POR (95% CI)*POR (95% CI)§P
Entire sampleGG186 (33.2)198 (27.5)1.60 (1.17-2.19)4.0 × 10−31.68 (1.21-2.33)2.2 × 10−31.69 (1.19-2.40)9.5 × 10−3
GT272 (48.5)348 (48.3)1.33 (0.99-1.78)1.39 (1.03-1.88)1.45 (1.05-2.00)
TT103 (18.4)175 (24.3)1.0 (referent)1.0 (referent)1.0 (referent)
CaucasiansGG165 (31.3)177 (26.1)1.55 (1.12-2.14)8.6 × 10−31.62 (1.16-2.26)5.6 × 10−31.61 (1.36-2.30)0.013
GT259 (49.2)331 (48.8)1.30 (0.97-1.74)1.35 (1.00-1.83)1.41 (1.02-1.94)
TT103 (19.5)171 (25.2)1.0 (referent)1.0 (referent)1.0 (referent)
  • * ORs and 95% CI estimates for unconstrained genotype effect adjusted for age.

  • Crude OR and 95% CI estimates for unconstrained genotype effect.

  • P for trend from additive model.

  • § OR and 95% CI estimates for unconstrained genotype effect adjusted for age, race, gender, family history, body mass index, and NSAID use (479 cases and 640 controls with data available).