Table 2.

Main characteristics of the study population

VariablesAdenomatous polyps, n (%)Hyperplastic polyps, n (%)Controls, n (%)
Total N530202649
Age (y)58.0 ± 9.753.6 ± 9.952.9 ± 11.0
Sex
    Male331 (62.2)116 (57.4)251 (38.6)
    Female201 (37.8)86 (42.6)399 (61.4)
Folate intake (μg)
    <268170 (32.4)62 (31.3)213 (33.8)
    268-440190 (36.2)72 (36.4)203 (32.2)
    >440165 (31.4)64 (32.3)215 (34.1)
Methionine intake (g)
    <1.55165 (31.4)71 (35.9)217 (34.4)
    1.55-2.16177 (33.7)63 (31.8)197 (31.2)
    >2.17183 (34.9)64 (32.3)217 (34.4)
Alcohol intake (g)*
    0202 (38.6)64 (32.3)283 (44.9)
    1-7128 (24.5)53 (26.8)185 (29.4)
    8-25122 (23.3)54 (27.3)116 (18.4)
    >2671 (13.6)27 (13.6)46 (7.3)
DNMT3b −149C>T genotype
    C/C167 (31.8)53 (27.3)216 (34.7)
    C/T250 (47.7)106 (54.6)300 (48.2)
    T/T107 (20.4)35 (18.0)106 (17.0)
DNMT3b −283T>C genotype
    T/T186 (35.5)61 (31.6)235 (37.8)
    T/C243 (46.4)105 (54.4)291 (46.9)
    C/C95 (18.1)27 (14.0)95 (15.3)
DNMT3b −579G>T genotype
    G/G190 (36.1)60 (31.1)239 (38.4)
    G/T237 (45.1)102 (52.9)288 (46.3)
    T/T98 (18.7)31 (16.1)95 (15.3)
ADH1C genotype
    *1/*1177 (34.0)74 (38.3)220 (35.4)
    *1/*2251 (48.3)86 (44.6)299 (48.1)
    *2/*292 (17.5)33 (17.1)103 (16.6)
DNMT3b haplotype (−149C>T, −283T>C, −579G>T)
    CCG1.20.71.2
    CCT0.20.30.6
    CTG53.852.756.6
    CTT0.50.80.4
    TCG0.10.10.1
    TCT39.840.336.9
    TTG3.84.13.7
    TTT0.61.00.6
  • NOTE: The pairwise R2 for the three polymorphisms were 0.76 between −149C>T and −283T>C, 0.80 between −149C>T and −579G>T, and 0.90 between −283T>C and −579G>T.

  • * Alcohol intake was assessed in grams per day.

  • Percentages rather than total N are reported for haplotypes because they are inferred rather than determined.